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rdf:type |
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lifeskim:mentions |
umls-concept:C0030705,
umls-concept:C0032854,
umls-concept:C0039286,
umls-concept:C0080055,
umls-concept:C0087111,
umls-concept:C0278493,
umls-concept:C0681842,
umls-concept:C0871261,
umls-concept:C1561558,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1998-1-27
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pubmed:abstractText |
Mutations of the p53 gene are frequently observed in primary breast cancer and accumulation of p53 protein has been used as a surrogate marker of p53 inactivation. Previous studies have shown that p53 accumulation is related to poor prognosis in primary breast cancer. We studied whether p53 protein accumulation is a predictive factor for response to tamoxifen treatment in patients with recurrent breast cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0732-183X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9440732-Adult,
pubmed-meshheading:9440732-Aged,
pubmed-meshheading:9440732-Aged, 80 and over,
pubmed-meshheading:9440732-Analysis of Variance,
pubmed-meshheading:9440732-Antineoplastic Agents, Hormonal,
pubmed-meshheading:9440732-Breast Neoplasms,
pubmed-meshheading:9440732-Female,
pubmed-meshheading:9440732-Humans,
pubmed-meshheading:9440732-Middle Aged,
pubmed-meshheading:9440732-Neoplasm Proteins,
pubmed-meshheading:9440732-Neoplasm Recurrence, Local,
pubmed-meshheading:9440732-Predictive Value of Tests,
pubmed-meshheading:9440732-Proportional Hazards Models,
pubmed-meshheading:9440732-Receptors, Estrogen,
pubmed-meshheading:9440732-Receptors, Progesterone,
pubmed-meshheading:9440732-Regression Analysis,
pubmed-meshheading:9440732-Survival Analysis,
pubmed-meshheading:9440732-Tamoxifen,
pubmed-meshheading:9440732-Tumor Suppressor Protein p53
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pubmed:year |
1998
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pubmed:articleTitle |
p53 protein accumulation predicts poor response to tamoxifen therapy of patients with recurrent breast cancer.
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pubmed:affiliation |
Department of Medical Oncology, Rotterdam Cancer Institute, Daniel den Hoed Kliniek/University Hospital Rotterdam, The Netherlands. berns@bidh.azr.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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