Linked Life Data

9440617

Source:http://linkedlifedata.com/resource/pubmed/id/9440617

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1998-2-17
pubmed:abstractText
Anal ultra slow waves (USWs) have been described in a variety of anorectal disorders, all of which may be associated with constipation. We investigated whether they represent a marker for dyschezia and whether their occurrence can be modified. Manometric and endosonographic studies were performed in 25 patients with dyschezia, in 25 age- and sex-matched controls, and in an equal number of patients with hemorrhoids. Patients exhibiting ultra slow waves were repeatedly studied with and without local administration of isosorbide dinitrate. In addition, we determined whether stimulatory maneuvers modify the occurrence of USWs. Anal USWs were persistently found in 56% of patients with dyschezia, in 8% of patients with hemorrhoids, and in none of the healthy controls. They were stimulated by anal squeeze and completely abolished by local administration of isosorbide dinitrate. Ultra slow waves always occurred in conjunction with an increase in anal resting pressure and were tightly associated with a fluctuation in slow wave amplitude. Anal sphincter morphology was similar in patients with dyschezia and in controls. We conclude that anal USWs occur most frequently in patients with dyschezia and indicate smooth muscle dysfunction. Treatment directed at abolishing this motor phenomenon may represent a novel approach to the management of patients with dyschezia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0163-2116
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2439-45
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Anal ultra slow waves: a smooth muscle phenomenon associated with dyschezia.
pubmed:affiliation
Gastroenterologisches Institut Wiesbaden, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't