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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-2-17
|
| pubmed:abstractText |
The effect of administration of human recombinant erythropoietin on leukocytic cells has been evaluated. In humans the administration of 20,000 U i.v. of rHuEPO caused a rapid and transitory leukopenia that seemed to be caused by a preferential reduction of lymphocytes (2715 +/- 513 mm3 t 0; 1898 +/- 506 t 60', p < 0.002). Pretreatment with imidazole-2-hydroxybenzoate, a drug capable of inhibiting the synthesis of prostaglandins, caused a less marked and later reduction of lymphocytes (2242 +/- 477 t 0; 1560 +/- 318 t 180 minutes, p < 0.001). A less marked and later lymphocytopenia was also shown in subjects affected by chronic renal insufficiency (2907 +/- 726 t 0; 1944 +/- 512 t 180 minutes, p < 0.005).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1082-8893
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
13-7
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9439976-Erythropoietin,
pubmed-meshheading:9439976-Female,
pubmed-meshheading:9439976-Humans,
pubmed-meshheading:9439976-Infusions, Intravenous,
pubmed-meshheading:9439976-Lymphopenia,
pubmed-meshheading:9439976-Male,
pubmed-meshheading:9439976-Middle Aged,
pubmed-meshheading:9439976-Recombinant Proteins
|
| pubmed:articleTitle |
Rapid and transient lymphocytopenia after i.v. administration of high doses of human recombinant erythropoietin.
|
| pubmed:affiliation |
Department of Internal Medicine, University of Messina, Italy.
|
| pubmed:publicationType |
Journal Article
|