| pubmed-article:9438849 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9438849 | lifeskim:mentions | umls-concept:C0018330 | lld:lifeskim |
| pubmed-article:9438849 | lifeskim:mentions | umls-concept:C1621574 | lld:lifeskim |
| pubmed-article:9438849 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:9438849 | pubmed:issue | 5350 | lld:pubmed |
| pubmed-article:9438849 | pubmed:dateCreated | 1998-2-3 | lld:pubmed |
| pubmed-article:9438849 | pubmed:abstractText | The Son of Sevenless (Sos) proteins control receptor-mediated activation of Ras by catalyzing the exchange of guanosine diphosphate for guanosine triphosphate on Ras. The NH2-terminal region of Sos contains a Dbl homology (DH) domain in tandem with a pleckstrin homology (PH) domain. In COS-1 cells, the DH domain of Sos stimulated guanine nucleotide exchange on Rac but not Cdc42 in vitro and in vivo. The tandem DH-PH domain of Sos (DH-PH-Sos) was defective in Rac activation but regained Rac stimulating activity when it was coexpressed with activated Ras. Ras-mediated activation of DH-PH-Sos did not require activation of mitogen-activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase. These results reveal a potential mechanism for coupling of Ras and Rac signaling pathways. | lld:pubmed |
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| pubmed-article:9438849 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9438849 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9438849 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9438849 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:9438849 | pubmed:author | pubmed-author:Bar-SagiDD | lld:pubmed |
| pubmed-article:9438849 | pubmed:author | pubmed-author:YatsulaB ABA | lld:pubmed |
| pubmed-article:9438849 | pubmed:author | pubmed-author:NimnualA SAS | lld:pubmed |
| pubmed-article:9438849 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9438849 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:9438849 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:9438849 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9438849 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9438849 | pubmed:pagination | 560-3 | lld:pubmed |
| pubmed-article:9438849 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9438849 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9438849 | pubmed:articleTitle | Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. | lld:pubmed |
| pubmed-article:9438849 | pubmed:affiliation | Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA. | lld:pubmed |
| pubmed-article:9438849 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9438849 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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