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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5350
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pubmed:dateCreated |
1998-2-3
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pubmed:abstractText |
The Son of Sevenless (Sos) proteins control receptor-mediated activation of Ras by catalyzing the exchange of guanosine diphosphate for guanosine triphosphate on Ras. The NH2-terminal region of Sos contains a Dbl homology (DH) domain in tandem with a pleckstrin homology (PH) domain. In COS-1 cells, the DH domain of Sos stimulated guanine nucleotide exchange on Rac but not Cdc42 in vitro and in vivo. The tandem DH-PH domain of Sos (DH-PH-Sos) was defective in Rac activation but regained Rac stimulating activity when it was coexpressed with activated Ras. Ras-mediated activation of DH-PH-Sos did not require activation of mitogen-activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase. These results reveal a potential mechanism for coupling of Ras and Rac signaling pathways.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine Nucleotide Exchange Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MCF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Retroviridae Proteins, Oncogenic,
http://linkedlifedata.com/resource/pubmed/chemical/Son of Sevenless Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/cdc42 GTP-Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ras Guanine Nucleotide Exchange...,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
279
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
560-3
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9438849-Actins,
pubmed-meshheading:9438849-Animals,
pubmed-meshheading:9438849-COS Cells,
pubmed-meshheading:9438849-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9438849-Cell Cycle Proteins,
pubmed-meshheading:9438849-Cell Line,
pubmed-meshheading:9438849-Cell Membrane,
pubmed-meshheading:9438849-Enzyme Activation,
pubmed-meshheading:9438849-GTP Phosphohydrolases,
pubmed-meshheading:9438849-GTP-Binding Proteins,
pubmed-meshheading:9438849-Guanine Nucleotide Exchange Factors,
pubmed-meshheading:9438849-Guanosine Diphosphate,
pubmed-meshheading:9438849-Guanosine Triphosphate,
pubmed-meshheading:9438849-Humans,
pubmed-meshheading:9438849-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:9438849-Membrane Proteins,
pubmed-meshheading:9438849-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9438849-Proteins,
pubmed-meshheading:9438849-Proto-Oncogene Proteins,
pubmed-meshheading:9438849-Recombinant Fusion Proteins,
pubmed-meshheading:9438849-Retroviridae Proteins, Oncogenic,
pubmed-meshheading:9438849-Signal Transduction,
pubmed-meshheading:9438849-Son of Sevenless Proteins,
pubmed-meshheading:9438849-Transfection,
pubmed-meshheading:9438849-cdc42 GTP-Binding Protein,
pubmed-meshheading:9438849-rac GTP-Binding Proteins,
pubmed-meshheading:9438849-ras Guanine Nucleotide Exchange Factors,
pubmed-meshheading:9438849-ras Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.
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pubmed:affiliation |
Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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