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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-3-20
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pubmed:abstractText |
Passive avoidance learning and retention, as well as locomotor and exploratory behaviors, were assessed in rats after intraventricular 192 immunoglobulin G-saporin injections on either Postnatal Day 1 (PND1) or PND7. PND1-lesioned rats were not significantly impaired on acquisition or retention of passive avoidance. PND7-lesioned rats acquired the task slower than controls, but retention was not affected. PND7-lesioned rats were less exploratory than controls and showed reduced wall rearing. Histological analysis of PND1- and PND7-lesioned rats revealed no neuronal degeneration in hippocampus or cortex. There was a marked reduction of choline acetyltransferase (ChAT) activity in the hippocampus, cortex, and septum in the PND7-lesioned rats and a slight but significant ChAT depletion in the cortex of PND1-lesioned rats. These data suggest that the cholinergic system is critical for the learning of passive avoidance and exploratory behaviors in the developing rat.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Choline O-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Cholinergic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Immunotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/N-Glycosyl Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cholinergic,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosome Inactivating Proteins...,
http://linkedlifedata.com/resource/pubmed/chemical/Scopolamine Hydrobromide,
http://linkedlifedata.com/resource/pubmed/chemical/saporin
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0735-7044
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1292-302
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9438798-Animals,
pubmed-meshheading:9438798-Animals, Newborn,
pubmed-meshheading:9438798-Antibodies, Monoclonal,
pubmed-meshheading:9438798-Avoidance Learning,
pubmed-meshheading:9438798-Behavior, Animal,
pubmed-meshheading:9438798-Cerebral Cortex,
pubmed-meshheading:9438798-Choline O-Acetyltransferase,
pubmed-meshheading:9438798-Cholinergic Agents,
pubmed-meshheading:9438798-Cholinergic Fibers,
pubmed-meshheading:9438798-Exploratory Behavior,
pubmed-meshheading:9438798-Hippocampus,
pubmed-meshheading:9438798-Immunotoxins,
pubmed-meshheading:9438798-Muscarinic Antagonists,
pubmed-meshheading:9438798-N-Glycosyl Hydrolases,
pubmed-meshheading:9438798-Neural Pathways,
pubmed-meshheading:9438798-Plant Proteins,
pubmed-meshheading:9438798-Prosencephalon,
pubmed-meshheading:9438798-Rats,
pubmed-meshheading:9438798-Rats, Wistar,
pubmed-meshheading:9438798-Receptors, Cholinergic,
pubmed-meshheading:9438798-Ribosome Inactivating Proteins, Type 1,
pubmed-meshheading:9438798-Scopolamine Hydrobromide,
pubmed-meshheading:9438798-Time Factors
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pubmed:year |
1997
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pubmed:articleTitle |
Different effects of postnatal day 1 versus 7 192 immunoglobulin G-saporin lesions on learning, exploratory behaviors, and neurochemistry in juvenile rats.
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pubmed:affiliation |
Laboratorio di Fisiopatologia O.S, Istituto Superiore di Sanità, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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