| pubmed-article:9437437 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9437437 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:9437437 | lifeskim:mentions | umls-concept:C0007807 | lld:lifeskim |
| pubmed-article:9437437 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:9437437 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:9437437 | lifeskim:mentions | umls-concept:C0085151 | lld:lifeskim |
| pubmed-article:9437437 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:9437437 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:9437437 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9437437 | pubmed:dateCreated | 1998-3-6 | lld:pubmed |
| pubmed-article:9437437 | pubmed:abstractText | The authors compared concentrations of soluble beta-amyloid protein precursor (s beta PP) in cerebrospinal fluid (CSF) in 45 patients diagnosed with probable Alzheimer disease (AD) and 26 normal older control volunteers. Soluble beta-amyloid protein precursor concentrations were measured in 125 CSF samples using an enzyme-linked immunosorbent assay. All subjects had Mini-Mental State Examination (MMSE) and Clinical Dementia Rating Scale (CDRS) scores and assessment of disease duration. The s beta PP concentrations in CSF in the probable AD group (mean +/- SD = 493 +/- 268 micrograms/L) were decreased significantly compared with the age-matched control group (mean = 831 +/- 302 micrograms/L; p < 0.0001). In the probable AD group, MMSE scores correlated positively with s beta PP concentrations (correlation coefficient r = 0.53, p < 0.0001), and CDRS ratings and disease duration correlated inversely with s beta PP concentrations (r = -0.59, p < 0.0001 and r = -0.479, p = 0.0006, respectively). Although the decrease in CSF s beta PP from levels found in healthy elderly controls was significant in AD subjects, there was substantial overlap. In AD, CSF s beta PP was most reduced in patients in later stages of the disease. The s beta PP concentrations reflect disease severity, but utility in differential diagnosis has not been determined. | lld:pubmed |
| pubmed-article:9437437 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9437437 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9437437 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9437437 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9437437 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9437437 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9437437 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9437437 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9437437 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9437437 | pubmed:issn | 0893-0341 | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:RaskindM AMA | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:PandianM RMR | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:SchellenbergG... | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:NochlinDD | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:ClevelandMM | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:WagnerS LSL | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:FarlowM RMR | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:PeskindE RER | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:SiegelR SRS | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:MorganC HCH | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:CorbinSS | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:ItoR KRK | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:ProvowS ASA | lld:pubmed |
| pubmed-article:9437437 | pubmed:author | pubmed-author:LeverenzJJ | lld:pubmed |
| pubmed-article:9437437 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9437437 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:9437437 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9437437 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9437437 | pubmed:pagination | 201-6 | lld:pubmed |
| pubmed-article:9437437 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:meshHeading | pubmed-meshheading:9437437-... | lld:pubmed |
| pubmed-article:9437437 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9437437 | pubmed:articleTitle | Clinicopathologic correlations of soluble amyloid beta-protein precursor in cerebrospinal fluid in patients with Alzheimer disease and controls. | lld:pubmed |
| pubmed-article:9437437 | pubmed:affiliation | Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA. | lld:pubmed |
| pubmed-article:9437437 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9437437 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9437437 | lld:pubmed |
