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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-3-6
|
| pubmed:abstractText |
The authors compared concentrations of soluble beta-amyloid protein precursor (s beta PP) in cerebrospinal fluid (CSF) in 45 patients diagnosed with probable Alzheimer disease (AD) and 26 normal older control volunteers. Soluble beta-amyloid protein precursor concentrations were measured in 125 CSF samples using an enzyme-linked immunosorbent assay. All subjects had Mini-Mental State Examination (MMSE) and Clinical Dementia Rating Scale (CDRS) scores and assessment of disease duration. The s beta PP concentrations in CSF in the probable AD group (mean +/- SD = 493 +/- 268 micrograms/L) were decreased significantly compared with the age-matched control group (mean = 831 +/- 302 micrograms/L; p < 0.0001). In the probable AD group, MMSE scores correlated positively with s beta PP concentrations (correlation coefficient r = 0.53, p < 0.0001), and CDRS ratings and disease duration correlated inversely with s beta PP concentrations (r = -0.59, p < 0.0001 and r = -0.479, p = 0.0006, respectively). Although the decrease in CSF s beta PP from levels found in healthy elderly controls was significant in AD subjects, there was substantial overlap. In AD, CSF s beta PP was most reduced in patients in later stages of the disease. The s beta PP concentrations reflect disease severity, but utility in differential diagnosis has not been determined.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0893-0341
|
| pubmed:author |
pubmed-author:ClevelandMM,
pubmed-author:CorbinSS,
pubmed-author:FarlowM RMR,
pubmed-author:ItoR KRK,
pubmed-author:LeverenzJJ,
pubmed-author:MorganC HCH,
pubmed-author:NochlinDD,
pubmed-author:PandianM RMR,
pubmed-author:PeskindE RER,
pubmed-author:ProvowS ASA,
pubmed-author:RaskindM AMA,
pubmed-author:SchellenbergG DGD,
pubmed-author:SiegelR SRS,
pubmed-author:WagnerS LSL
|
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
201-6
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9437437-Aged,
pubmed-meshheading:9437437-Aged, 80 and over,
pubmed-meshheading:9437437-Alzheimer Disease,
pubmed-meshheading:9437437-Amyloid beta-Protein Precursor,
pubmed-meshheading:9437437-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:9437437-Female,
pubmed-meshheading:9437437-Humans,
pubmed-meshheading:9437437-Male,
pubmed-meshheading:9437437-Middle Aged,
pubmed-meshheading:9437437-Osmolar Concentration,
pubmed-meshheading:9437437-Psychiatric Status Rating Scales,
pubmed-meshheading:9437437-Reference Values,
pubmed-meshheading:9437437-Solubility
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Clinicopathologic correlations of soluble amyloid beta-protein precursor in cerebrospinal fluid in patients with Alzheimer disease and controls.
|
| pubmed:affiliation |
Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|