9436980

pubmed:Citation

2

Genetic analysis in Arabidopsis has led to the identification of several genes that are required for auxin response. One of these genes, AXR1, encodes a protein related to yeast Aos1p, a protein that functions to activate the ubiquitin-related protein Smt3p. Here we report the identification of a new gene called TRANSPORT INHIBITOR RESPONSE 1 (TIR1). The tir1 mutants are deficient in a variety of auxin-regulated growth processes including hypocotyl elongation and lateral root formation. These results indicate that TIR1 is also required for normal response to auxin. Further, mutations in TIR1 display a synergistic interaction with mutations in AXR1, suggesting that the two genes function in overlapping pathways. The TIR1 protein contains a series of leucine-rich repeats and a recently identified motif called an F box. Sequence comparisons indicate that TIR1 is related to the yeast protein Grr1p and the human protein SKP2. Because Grr1p and other F-box proteins have been implicated in ubiquitin-mediated processes, we speculate that auxin response depends on the modification of a key regulatory protein(s) by ubiquitin or a ubiquitin-related protein.

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http://linkedlifedata.com/resource/pubmed/journal/8711660

http://linkedlifedata.com/resource/pubmed/chemical/2,4-Dichlorophenoxyacetic Acid, http://linkedlifedata.com/resource/pubmed/chemical/AXR1 protein, Arabidopsis, http://linkedlifedata.com/resource/pubmed/chemical/Arabidopsis Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances, http://linkedlifedata.com/resource/pubmed/chemical/Indoleacetic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Phthalimides, http://linkedlifedata.com/resource/pubmed/chemical/Plant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/alpha Karyopherins, http://linkedlifedata.com/resource/pubmed/chemical/alpha-naphthylphthalamic acid

Jan

pubmed-author:DeweyEE, pubmed-author:EstelleMM, pubmed-author:GrayW MWM, pubmed-author:HobbieLL, pubmed-author:RueggerMM, pubmed-author:TurnerJJ

15

NLM

198-207

pubmed-meshheading:9436980-2,4-Dichlorophenoxyacetic Acid, pubmed-meshheading:9436980-Amino Acid Sequence, pubmed-meshheading:9436980-Arabidopsis, pubmed-meshheading:9436980-Arabidopsis Proteins, pubmed-meshheading:9436980-Cell Division, pubmed-meshheading:9436980-Genes, Plant, pubmed-meshheading:9436980-Genes, Recessive, pubmed-meshheading:9436980-Genotype, pubmed-meshheading:9436980-Growth Substances, pubmed-meshheading:9436980-Indoleacetic Acids, pubmed-meshheading:9436980-Molecular Sequence Data, pubmed-meshheading:9436980-Mutation, pubmed-meshheading:9436980-Nuclear Proteins, pubmed-meshheading:9436980-Phthalimides, pubmed-meshheading:9436980-Plant Proteins, pubmed-meshheading:9436980-Plant Roots, pubmed-meshheading:9436980-alpha Karyopherins

The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast grr1p.