Linked Life Data

9434180

Source:http://linkedlifedata.com/resource/pubmed/id/9434180

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1998-2-12
pubmed:databankReference
pubmed:abstractText
We have identified a highly polymorphic pentanucleotide repeat (CCTTT)n within the 5'-putative promoter region of the human inducible nitric oxide synthase gene (iNOS, NOS2). Using a pair of specific primers derived from the human iNOS gene, we have also amplified this iNOS repeat in DNA from the following species: chimpanzee, gorilla, orangutan and macaque. As is found in man, both chimpanzees and gorillas are polymorphic at this locus. In contrast, the locus is monomorphic in macaques and orangutans. While the average number of repeats is similar in gorilla and man, there are considerably fewer repeats in chimpanzees. A comparison of the sequences flanking the (CCTTT)n repeats among these closely related species demonstrates the presence of long stretches of homopurine-homopyrimidine residues. Similar polypurine/polypyrimidine stretches have been identified in the promoter regions of a number of other vertebrate genes where they have been associated with transcriptional regulation, although a role for the (CCTTT)n repeat array in the human iNOS gene has not yet been demonstrated.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0378-1119
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
204
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-70
pubmed:dateRevised
2011-10-27
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Evolution of a homopurine-homopyrimidine pentanucleotide repeat sequence upstream of the human inducible nitric oxide synthase gene.
pubmed:affiliation
The Cruciform Project, The Rayne Institute, University College London, UK.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't