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rdf:type |
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lifeskim:mentions |
umls-concept:C0012472,
umls-concept:C0033268,
umls-concept:C0077273,
umls-concept:C0181209,
umls-concept:C0205263,
umls-concept:C0387583,
umls-concept:C0441655,
umls-concept:C1280500,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C2752151,
umls-concept:C2828366
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pubmed:issue |
1
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pubmed:dateCreated |
1998-1-29
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pubmed:abstractText |
Extracts of the Chinese herbal remedy Tripterygium wilfordii Hook F (TWHF) have been reported to be effective in the treatment of patients with a variety of inflammatory and autoimmune diseases, but the mechanism of this therapeutic effect has not been completely delineated. The present study was designed to assess the effects of TWHF on the in vitro synthesis of prostaglandin E2 (PGE2) and on the expression of the cyclooxygenase isoforms, COX-1 and COX-2, in various human cell types.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetates,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Chloroform,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Diterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Epoxy Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Methanol,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxidases,
http://linkedlifedata.com/resource/pubmed/chemical/Phenanthrenes,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/ethyl acetate,
http://linkedlifedata.com/resource/pubmed/chemical/triptolide
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
130-8
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:9433878-Acetates,
pubmed-meshheading:9433878-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:9433878-Chloroform,
pubmed-meshheading:9433878-Cyclooxygenase 1,
pubmed-meshheading:9433878-Cyclooxygenase 2,
pubmed-meshheading:9433878-Dinoprostone,
pubmed-meshheading:9433878-Diterpenes,
pubmed-meshheading:9433878-Drugs, Chinese Herbal,
pubmed-meshheading:9433878-Epoxy Compounds,
pubmed-meshheading:9433878-Gene Expression Regulation,
pubmed-meshheading:9433878-Humans,
pubmed-meshheading:9433878-Interleukin-2,
pubmed-meshheading:9433878-Isoenzymes,
pubmed-meshheading:9433878-Kinetics,
pubmed-meshheading:9433878-Lipopolysaccharides,
pubmed-meshheading:9433878-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:9433878-Membrane Proteins,
pubmed-meshheading:9433878-Methanol,
pubmed-meshheading:9433878-Monocytes,
pubmed-meshheading:9433878-Peroxidases,
pubmed-meshheading:9433878-Phenanthrenes,
pubmed-meshheading:9433878-Plant Extracts,
pubmed-meshheading:9433878-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:9433878-RNA, Messenger,
pubmed-meshheading:9433878-Tripterygium,
pubmed-meshheading:9433878-Tumor Cells, Cultured
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pubmed:year |
1998
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pubmed:articleTitle |
Effects of Tripterygium wilfordii hook F extracts on induction of cyclooxygenase 2 activity and prostaglandin E2 production.
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pubmed:affiliation |
University of Texas Southwestern Medical Center at Dallas, 75235-8884, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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