Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-2-19
|
| pubmed:abstractText |
We find a meta-data set (715 families, up to 1,124 sib pairs) for bipolar illness to have a strong signal in a 10 cM region around D18S40, and excess paternal sharing on the q arm near marker D18S64. We describe a method for meta-analysis of microsatellite marker data using affected sib-pair (ASP) methodology. Inherent difficulties in such analysis include heterogeneity of allele frequencies and protocol design, measurement errors in genotyping, and map construction. Using identity-by-descent (IBD) allele sharing as the dependent variable, a logistic regression to test for heterogeneity finds only mild heterogeneity, and a limited parent-of-origin effect.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0741-0395
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
617-22
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9433552-Alleles,
pubmed-meshheading:9433552-Bipolar Disorder,
pubmed-meshheading:9433552-Chromosomes, Human, Pair 18,
pubmed-meshheading:9433552-Female,
pubmed-meshheading:9433552-Genetic Linkage,
pubmed-meshheading:9433552-Genotype,
pubmed-meshheading:9433552-Humans,
pubmed-meshheading:9433552-Male,
pubmed-meshheading:9433552-Matched-Pair Analysis,
pubmed-meshheading:9433552-Nuclear Family
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
A meta-analysis of chromosome 18 linkage data for bipolar illness.
|
| pubmed:affiliation |
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Meta-Analysis
|