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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-2-3
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pubmed:abstractText |
Efficient loading of major histocompatibility complex class II molecules with peptides requires the invariant chain (Ii) and the class II-like molecule H-2M. Recent in vitro biochemical studies suggest that H2-M may function as a chaperone to rescue empty class II dimers. To test this hypothesis in vivo, we generated mice lacking both Ii and H-2M (Ii-/-M-/-). Antigen presenting cells (APCs) from Ii-/-M-/- mice, as compared with APCs from Ii-/- mice, exhibit a significant reduction in their ability to present self-peptides to a panel of class II I-Ab-restricted T cells. As a consequence of this defect in the loading of self peptides, CD4(+) thymocyte development is profoundly impaired in Ii-/-M-/- mice, resulting in a peripheral CD4(+) T cell population with low levels of T cell receptor expression. These findings are consistent with the idea that H-2M functions as a chaperone in the peptide loading of class II molecules in vivo.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-1656278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-17708922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-1967485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-2166918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-7510069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-7540726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-7596415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-7600303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-7606781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-7648393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-7679955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-7895165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-7947465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-7985027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8098731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8176208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8515815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8574855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8598037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8598040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8598041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8617217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8638109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8775461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8775463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8976171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-8977167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-9029086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-9057358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-9075930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-9256469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9432982-9285405
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-51
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9432982-Animals,
pubmed-meshheading:9432982-Antigen Presentation,
pubmed-meshheading:9432982-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:9432982-Autoantigens,
pubmed-meshheading:9432982-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9432982-Cell Differentiation,
pubmed-meshheading:9432982-H-2 Antigens,
pubmed-meshheading:9432982-Histocompatibility Antigens Class II,
pubmed-meshheading:9432982-Macromolecular Substances,
pubmed-meshheading:9432982-Mice,
pubmed-meshheading:9432982-Mice, Inbred C57BL,
pubmed-meshheading:9432982-Mice, Knockout,
pubmed-meshheading:9432982-Peptides,
pubmed-meshheading:9432982-Protein Binding
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pubmed:year |
1998
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pubmed:articleTitle |
Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo.
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pubmed:affiliation |
Department of Immunology, University of Washington School of Medicine, Seattle 98195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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