Linked Life Data

9431893

Source:http://linkedlifedata.com/resource/pubmed/id/9431893

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1998-2-11
pubmed:abstractText
The major experimental and intellectual advance in gastroenterology in recent years has been the observation that mice with deletions in specific cytokine genes develop a spontaneous inflammatory bowel disease. Inflammatory bowel disease has also been seen in a number of other mouse strains with perturbed immune responses. The driving force for disease in a number of these models is the normal bacterial flora. These studies show that the gut immune system is in homeostasis with the antigens of the flora, but inappropriate T-helper 1 (Th1)-type responses to the flora cause severe gut injury and since the antigenic stimulus persists, the consequence is chronic inflammation.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0954-691X
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1051-5
pubmed:dateRevised
2009-10-16
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Cytokine gene deleted mice in the study of gastrointestinal inflammation.
pubmed:affiliation
Department of Paediatric Gastroenterology, St Bartholomew's and the Royal London School of Medicine and Dentistry, St Bartholomew's Hospital, UK.
pubmed:publicationType
Journal Article, Review