Linked Life Data

9431550

Source:http://linkedlifedata.com/resource/pubmed/id/9431550

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-2-18
pubmed:abstractText
The possibility of changes in binding sites for calcitonin gene-related peptide (CGRP) in response to sensorial denervation was studied in rats after pyridoxine-induced neurotoxicity. Changes in CGRP binding sites were evaluated by an in vitro autoradiographic technique using [125I]-Tyr-rat-CGRP as a ligand. A bidirectional binding response was obtained: an increased binding, in comparison with the respective control, was observed in spinal cord and cerebellar regions whereas a decreased binding was noted in cerebrum. CGRP binding in selective areas comparising the pathways that are responsible for transmitting sensory impulses have shown significant changes. These results suggest that CGRP plays a modulatory role in the central nervous system. This study has also proposed and evaluated pyridoxine toxicity as a model for studying sensory denervation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1230-6002
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Effects of pyridoxine neurotoxicity on a distribution of calcitonin gene-related peptide binding sites.
pubmed:affiliation
Adnan Menderes University, School of Medicine, Department of Pharmacology, Aydin, Turkey.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't