Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-2-19
|
| pubmed:abstractText |
Using the senescence-accelerated mouse (SAM) strains, we examined the senescence-related changes of autologous mixed-lymphocyte reaction (AMLR) as well as the phenotypic alteration of the T cell subsets. Splenic T cells from senescence-prone (SAM-P) and resistant (SAM-R) strains of mice were incubated with autologous non-T cells, and AMLR was measured on day 1-5. The kinetics of AMLR responses revealed a marked alteration in senescent SAM-P but not in non-senescent SAM-R mice, in which the peak response occurred at day 1, the response decreasing thereafter up to day 5. Similar senescence-related change was observed in aged (24-month-old) SAM-R and BALB/c mice. Furthermore, the T cells from the aged SAM-R mice cultured with non-senescent syngeneic non-T cells showed a very similar pattern to that cultured with autologous non-T cells. Flow cytometric analysis of T cell phenotype indicated that the percentage of CD4+ CD45RBhi T cells correlated with the peak AMLR responses in both SAM-P and SAM-R mice, and that the percentage of the T cell subset with extrathymic properties was significantly higher in SAM-P mice. These findings suggest that the alteration in kinetics of AMLR is related to senescence but not to the strain of mice, and may reflect a senescence-related dysfunction of the autoregulatory immune mechanisms of T cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0047-6374
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
19-32
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9430102-Aging,
pubmed-meshheading:9430102-Animals,
pubmed-meshheading:9430102-Immunophenotyping,
pubmed-meshheading:9430102-Kinetics,
pubmed-meshheading:9430102-Mice,
pubmed-meshheading:9430102-Mice, Inbred BALB C,
pubmed-meshheading:9430102-Mice, Inbred Strains,
pubmed-meshheading:9430102-Spleen,
pubmed-meshheading:9430102-T-Lymphocyte Subsets,
pubmed-meshheading:9430102-Time Factors
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Senescence-related change in autologous mixed-lymphocyte reaction in senescence-accelerated mice.
|
| pubmed:affiliation |
Department of Oral Microbiology, Osaka University Faculty of Dentistry, Japan.
|
| pubmed:publicationType |
Journal Article
|