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rdf:type |
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lifeskim:mentions |
umls-concept:C0008643,
umls-concept:C0009013,
umls-concept:C0017337,
umls-concept:C0023418,
umls-concept:C0205147,
umls-concept:C0280100,
umls-concept:C1283195,
umls-concept:C1420708,
umls-concept:C1421408,
umls-concept:C1553877,
umls-concept:C1608885,
umls-concept:C1826758,
umls-concept:C1880274
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pubmed:issue |
2-3
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pubmed:dateCreated |
1998-1-27
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pubmed:databankReference |
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pubmed:abstractText |
By applying the 'recognition mask' strategy to 300 mammalian sequences containing NotI sites we demonstrated that 5' ends of genes are highly enriched in NotI sites. A NotI linking clone NL2-252 (D3S1678) containing transferrin receptor (TFRC) gene was used as an initial point for chromosomal jumping. One of the jumping clones, J21-045 traverses 210 kbp and links NL2-252 to NL26 (D3S1632), a NotI linking clone containing highly polymorphic sequences. The TFRC gene was mapped to 3q29, close to the telomeric marker D3S2344, by linkage analysis, a panel of hybrid cell lines, GeneBridge 4 panel and FISH. Clone NLM-007 (D3S4302) was found to contain ras-homologous gene RAB7. By FISH and a panel of hybrid cell lines this gene was mapped to 3q21. This region is of particular interest due to frequent rearrangements in different types of leukemia. Clone L2-081 (D3S4283) containing new member of ubiquitin-specific proteases (HAUSP gene) was localized in 3p21 inspiring further investigation of involvement of this gene in development of lung and renal carcinomas.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-5793
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pubmed:author |
pubmed-author:AllikmetsRR,
pubmed-author:BoldogFF,
pubmed-author:GizatullinR ZRZ,
pubmed-author:KashubaV IVI,
pubmed-author:KisselevLL,
pubmed-author:KleinGG,
pubmed-author:KorolevSS,
pubmed-author:MarcsekZZ,
pubmed-author:OOIS KSK,
pubmed-author:ProtopopovA IAI,
pubmed-author:SumegiJJ,
pubmed-author:TosuTT,
pubmed-author:ZabarovskaVV,
pubmed-author:ZabarovskyE RER
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
419
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9428630-Chromosome Mapping,
pubmed-meshheading:9428630-Chromosomes, Human, Pair 3,
pubmed-meshheading:9428630-Cloning, Molecular,
pubmed-meshheading:9428630-Endopeptidases,
pubmed-meshheading:9428630-GTP-Binding Proteins,
pubmed-meshheading:9428630-Gene Library,
pubmed-meshheading:9428630-Gene Rearrangement,
pubmed-meshheading:9428630-Genome, Human,
pubmed-meshheading:9428630-Humans,
pubmed-meshheading:9428630-Leukemia,
pubmed-meshheading:9428630-Molecular Sequence Data,
pubmed-meshheading:9428630-Neoplasms,
pubmed-meshheading:9428630-Receptors, Transferrin,
pubmed-meshheading:9428630-Ubiquitin Thiolesterase,
pubmed-meshheading:9428630-rab GTP-Binding Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukemia and deleted in solid tumors.
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pubmed:affiliation |
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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