Linked Life Data

9428350

Source:http://linkedlifedata.com/resource/pubmed/id/9428350

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6B
pubmed:dateCreated
1998-1-22
pubmed:abstractText
Although growth factors are acknowledged for their mitogenic activity, a number of other functions are fulfilled by such peptides. These include control of motile and invasive behaviour, angiogenesis and phenotype. Various growth factors including epidermal growth factor, fibroblast growth factor, platelet derived growth factor, transforming growth factor and vascular endothelial growth factor have been described in human glial tumours. These factors may act in either autocrine or paracrine loop systems to determine the malignant potential of intrinsic brain tumours. This review examines each of these factors and their various isoforms and outlines the influence they may exert on the behaviour of neoplastic glia. Moreover, the role of growth factors in the control of the various mechanisms which underlie diffuse infiltrative invasion, neovascularisation and proliferation are explored. Finally, the potential of growth factors and their receptors as therapeutic targets is considered.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4163-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
The role of growth factors in the malignant and invasive progression of intrinsic brain tumours.
pubmed:affiliation
Department of Neuropathology, Institute of Psychiatry, London, U.K.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't