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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-2-12
|
| pubmed:abstractText |
DL-alpha-tocopheryl acetate, a synthetic form of vitamin E, is routinely given as a dietary supplement to cattle. In this study we assessed the relative bioavailability of three formulations of DL-alpha-tocopheryl acetate in a kinetic study of plasma alpha-tocopherol in four Italian Friesian dairy cows, following intraruminal administration of a gelatin capsule containing 5,000 IU of DL-alpha-tocopheryl acetate. A Latin square design was used so that each animal received all formulations: (A) adsorbed on silica, (M) microencapsulated and (O) in oil form; 5,000 IU of DL-alpha-tocopheryl acetate was also administered intraperitoneally. The treatments were given following a 2-week period on a diet having no vitamin E supplementation with an interval of 8 days between each administration. Blood samples were collected at 0, 1, 10, 11, 21, 30, 48, 72, 96 and 168 h after each administration. The mean initial plasma alpha-tocopherol concentration (CO) was 2.38 +/- 0.57 micrograms/mL. Maximum plasma concentrations (Cmax) of alpha-tocopherol, adjusted for pretreatment values, were 3.90 +/- 0.13, 3.29 +/- 0.13 and 4.07 +/- 0.19 micrograms/mL, following administration of the A, M and O forms, respectively. The length of time required to obtain the maximum concentration (Tmax) in plasma was 57.5 +/- 7.8, 76.8 +/- 8.9 and 73.1 +/- 14.1 h, and the area under the curve (AUC) was 503.3 +/- 63, 620.25 +/- 108.5 and 465.4 +/- 38.7 micrograms.h/mL for A, M and O forms, respectively. Administration significantly increased the plasma alpha-tocopherol levels in all cases; however the A and M formulations had a lower elimination rate than the O form.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Capsules,
http://linkedlifedata.com/resource/pubmed/chemical/Oils,
http://linkedlifedata.com/resource/pubmed/chemical/Prodrugs,
http://linkedlifedata.com/resource/pubmed/chemical/Silicon Dioxide,
http://linkedlifedata.com/resource/pubmed/chemical/Tocopherols,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Tocopherol
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0928-4249
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
517-24
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9428145-Absorption,
pubmed-meshheading:9428145-Animals,
pubmed-meshheading:9428145-Area Under Curve,
pubmed-meshheading:9428145-Biological Availability,
pubmed-meshheading:9428145-Capsules,
pubmed-meshheading:9428145-Catheterization,
pubmed-meshheading:9428145-Cattle,
pubmed-meshheading:9428145-Chromatography, High Pressure Liquid,
pubmed-meshheading:9428145-Diet,
pubmed-meshheading:9428145-Dose-Response Relationship, Drug,
pubmed-meshheading:9428145-Drug Compounding,
pubmed-meshheading:9428145-Female,
pubmed-meshheading:9428145-Linear Models,
pubmed-meshheading:9428145-Milk,
pubmed-meshheading:9428145-Oils,
pubmed-meshheading:9428145-Prodrugs,
pubmed-meshheading:9428145-Rumen,
pubmed-meshheading:9428145-Silicon Dioxide,
pubmed-meshheading:9428145-Time Factors,
pubmed-meshheading:9428145-Tocopherols,
pubmed-meshheading:9428145-Vitamin E,
pubmed-meshheading:9428145-alpha-Tocopherol
|
| pubmed:articleTitle |
Relative bioavailability of vitamin E in dairy cows following intraruminal administration of three different preparations of DL-alpha-tocopheryl acetate.
|
| pubmed:affiliation |
Istituto di Alimentazione Animale, Facoltà di Medicina Veterinaria, Milan, Italy. alivet@imiucca.csi.unimi.it
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|