Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-2-12
|
| pubmed:abstractText |
Tyr-Phe and Met limitation in vitro inhibited cell proliferation and proliferating cell nuclear antigen (PCNA) expression to a greater extent than serum limitation. Tyr-Phe and serum limitation arrested cells in the G0/G1 phase; Met limitation blocked cells in the G0/G1 and S phases. Tyr-Phe limitation progressively decreased cyclin D1 expression to 30% of control within four days and did not affect expression of cyclin D3 or cyclin-dependent kinase (CDK2, CDK4, and CDK5) expression, Met limitation decreased cyclin D3 expression to 25% of control and CDK2 expression to 32% of control by Day 4 and did not affect expression of cyclin D1, CDK4, and CDK5. Serum limitation inhibited cyclin D1 and cyclin D3 expression to 24% of control after four days and did not effect CDK expression. Expression of two CDK inhibitors, p21WAF1/Cip1 and p27Kip1, was not changed by amino acid or serum limitation. Dietary restriction of Tyr-Phe in mice bearing subcutaneous B16BL6 melanoma tumors decreased tumor growth rate compared with mice fed a normal diet. Tumors from Tyr-Phe-restricted mice exhibited decreased PCNA expression, G0/G1 phase cell cycle arrest, and reduced cyclin D1 expression. These data indicate that decreased tumor growth in vivo associated with dietary restriction of Tyr and Phe is cell cycle specific.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Immune Sera,
http://linkedlifedata.com/resource/pubmed/chemical/Methionine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylalanine,
http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0163-5581
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
104-13
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9427972-Animals,
pubmed-meshheading:9427972-Antibodies, Monoclonal,
pubmed-meshheading:9427972-Blotting, Western,
pubmed-meshheading:9427972-Cell Cycle,
pubmed-meshheading:9427972-Culture Media,
pubmed-meshheading:9427972-Cyclins,
pubmed-meshheading:9427972-Diet,
pubmed-meshheading:9427972-Female,
pubmed-meshheading:9427972-Flow Cytometry,
pubmed-meshheading:9427972-Immune Sera,
pubmed-meshheading:9427972-Melanoma, Experimental,
pubmed-meshheading:9427972-Methionine,
pubmed-meshheading:9427972-Mice,
pubmed-meshheading:9427972-Phenylalanine,
pubmed-meshheading:9427972-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:9427972-Rabbits,
pubmed-meshheading:9427972-Rats,
pubmed-meshheading:9427972-Specific Pathogen-Free Organisms,
pubmed-meshheading:9427972-Time Factors,
pubmed-meshheading:9427972-Tumor Cells, Cultured,
pubmed-meshheading:9427972-Tyrosine
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Tyrosine and phenylalanine restriction induces G0/G1 cell cycle arrest in murine melanoma in vitro and in vivo.
|
| pubmed:affiliation |
Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman 99164-6510, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|