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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-2-26
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pubmed:databankReference |
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pubmed:abstractText |
During Xenopus early development, gene expression is regulated mainly at the translational level by the length of the poly(A) tail of mRNAs. The Eg family and c-mos maternal mRNAs are deadenylated rapidly and translationally repressed after fertilization. Here, we characterize a short sequence element (EDEN) responsible for the rapid deadenylation of Eg5 mRNA. Determining the core EDEN sequence permitted us to localize the c-mos EDEN sequence. The c-mos EDEN confered a rapid deadenylation to a reporter gene. The EDEN-specific RNA-binding protein (EDEN-BP) was purified and a cDNA obtained. EDEN-BP is highly homologous to a human protein possibly involved in myotonic dystrophy. Immunodepleting EDEN-BP from an egg extract totally abolished the EDEN-mediated deadenylation activity, but did not affect the default deadenylation activity. Therefore, EDEN-BP constitutes the first trans-acting factor for which an essential role in the specificity of mRNA deadenylation has been directly demonstrated.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-1285126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-1295736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-1606611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-1682219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-1700272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-1761057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-1973075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-1980656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-1980657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-2358121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-2458900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-2468559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-2531292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-2557628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-2568313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-2628165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-2673535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-2751084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-2971141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-3881765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-6207484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-7543316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-7736570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-7753842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-7801127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-7926777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-7969126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8036511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8065320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8114721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8452213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8548657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8550599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8595555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8816488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8871564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8915529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8948631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8972201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8994264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-8994266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9427761-9343673
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
278-87
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9427761-Adenine,
pubmed-meshheading:9427761-Amino Acid Sequence,
pubmed-meshheading:9427761-Animals,
pubmed-meshheading:9427761-Binding Sites,
pubmed-meshheading:9427761-Cloning, Molecular,
pubmed-meshheading:9427761-Molecular Sequence Data,
pubmed-meshheading:9427761-Mutagenesis,
pubmed-meshheading:9427761-Mutation,
pubmed-meshheading:9427761-Protein Binding,
pubmed-meshheading:9427761-Proto-Oncogene Proteins c-mos,
pubmed-meshheading:9427761-RNA, Messenger,
pubmed-meshheading:9427761-RNA-Binding Proteins,
pubmed-meshheading:9427761-Sequence Deletion,
pubmed-meshheading:9427761-Tumor Suppressor Protein p53,
pubmed-meshheading:9427761-Xenopus,
pubmed-meshheading:9427761-Xenopus Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
EDEN and EDEN-BP, a cis element and an associated factor that mediate sequence-specific mRNA deadenylation in Xenopus embryos.
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pubmed:affiliation |
CNRS UPR 41, Université de Rennes 1, Campus de Beaulieu, 35042 Rennes cedex, France.
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