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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1998-2-17
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pubmed:abstractText |
The cloning and pharmacological characterization of mouse 5-HT1D receptors as well as the comparative analysis of its embryonic expression vs that of 5-HT1B receptors are reported. High densities of both 5-HT1D receptors mRNA and specific 5-HT1D binding sites were detected at 8, 9.5, 10.5 and 13.5 days of prenatal development. In contrast, no specific 5-HT1B binding sites could be detected until 13.5 days of development, when they were present at lower levels than 5-HT1D receptors. This differs markedly from the situation in the adult brain, in which 5-HT1B receptors are present at a much higher density than the 5-HT1D subtype. These data suggest the involvement of 5-HT1D receptors in the mitogenic and proliferative effects of serotonin during early embryonic development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/HTR1B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1B,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1D,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3655-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9427346-Amino Acid Sequence,
pubmed-meshheading:9427346-Animals,
pubmed-meshheading:9427346-Base Sequence,
pubmed-meshheading:9427346-COS Cells,
pubmed-meshheading:9427346-Conserved Sequence,
pubmed-meshheading:9427346-DNA Primers,
pubmed-meshheading:9427346-Embryonic and Fetal Development,
pubmed-meshheading:9427346-Gene Expression Regulation, Developmental,
pubmed-meshheading:9427346-Genomic Library,
pubmed-meshheading:9427346-Humans,
pubmed-meshheading:9427346-Mice,
pubmed-meshheading:9427346-Molecular Sequence Data,
pubmed-meshheading:9427346-Polymerase Chain Reaction,
pubmed-meshheading:9427346-Protein Biosynthesis,
pubmed-meshheading:9427346-RNA, Messenger,
pubmed-meshheading:9427346-Radioligand Assay,
pubmed-meshheading:9427346-Rats,
pubmed-meshheading:9427346-Receptor, Serotonin, 5-HT1B,
pubmed-meshheading:9427346-Receptor, Serotonin, 5-HT1D,
pubmed-meshheading:9427346-Receptors, Serotonin,
pubmed-meshheading:9427346-Recombinant Proteins,
pubmed-meshheading:9427346-Sequence Alignment,
pubmed-meshheading:9427346-Transcription, Genetic,
pubmed-meshheading:9427346-Transfection
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pubmed:year |
1997
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pubmed:articleTitle |
Preferential expression of 5-HT1D over 5-HT1B receptors during early embryogenesis.
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pubmed:affiliation |
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université Louis Pasteur de Strasbourg, CNRS, INSERM, BP 163, Illkirch, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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