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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1998-2-17
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pubmed:abstractText |
A polymorphism in the beta 3-adrenergic receptor (beta 3-AR) has been described and consists of an amino acid substitution at position 64 where tryptophan is replaced by arginine (Arg allele). This polymorphism appears to be a modest contributor to obesity and non-insulin dependent diabetes mellitus (NIDDM), and may be dependent on gender, gene dosage, ethnic background and environmental factors. We have investigated whether the Trp64Arg polymorphism of the beta 3-AR was associated with body mass index (BMI), blood pressure or the presence of NIDDM in Alaskan Eskimos.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0307-0565
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1176-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9426386-Adult,
pubmed-meshheading:9426386-Alaska,
pubmed-meshheading:9426386-Alleles,
pubmed-meshheading:9426386-Arginine,
pubmed-meshheading:9426386-Asian Continental Ancestry Group,
pubmed-meshheading:9426386-Blood Pressure,
pubmed-meshheading:9426386-Body Mass Index,
pubmed-meshheading:9426386-Diabetes Mellitus, Type 2,
pubmed-meshheading:9426386-Female,
pubmed-meshheading:9426386-Gene Frequency,
pubmed-meshheading:9426386-Genotype,
pubmed-meshheading:9426386-Humans,
pubmed-meshheading:9426386-Inuits,
pubmed-meshheading:9426386-Male,
pubmed-meshheading:9426386-Middle Aged,
pubmed-meshheading:9426386-Obesity,
pubmed-meshheading:9426386-Phenotype,
pubmed-meshheading:9426386-Polymorphism, Genetic,
pubmed-meshheading:9426386-Receptors, Adrenergic, beta,
pubmed-meshheading:9426386-Tryptophan
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pubmed:year |
1997
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pubmed:articleTitle |
The beta(3)-adrenergic receptor TRP64ARG polymorphism and obesity in Alaskan Eskimos.
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pubmed:affiliation |
Department of Chemistry and Biochemistry, University of Alaska, Fairbanks 99775-7000, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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