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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-2-2
|
| pubmed:abstractText |
Predictive criteria for a first variceal hemorrhage lack substantial accuracy. Cross-sectional studies suggest a close relationship between variceal pressure (VP) and the occurrence of variceal bleeding. In the present prospective cohort study, the significance of VP measurement for prediction of a first variceal bleed was assessed. Eighty-seven patients with cirrhosis and large esophageal varices who had never developed variceal bleeding were followed for 12 months. The endpoint of the study was the presentation or not of a variceal hemorrhage. Thirty-four patients (39%) were in Child's class A, 37 in class B (43%), and 16 in class C (18%). The median interval between endoscopic diagnosis of varices and the beginning of the study was 15 months. Twenty-eight patients (32%) developed a variceal hemorrhage with a bleeding-related mortality of 18% (n=5). The 1-year mortality overall was 16% (n=14). Variables predictive of a first bleed identified by Cox proportional hazards regression model were: the level of VP, the North Italian Endoscopic Club (NIEC) score, and the interval between the diagnosis of varices and the start of the study. By adding VP to NIEC, a significant gain in prognostic accuracy was obtained (P = .003). In conclusion, the present study provides evidence that the level of VP is a major predictive factor for variceal hemorrhage, and that it provides further prognostic information in addition to the NIEC index.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0270-9139
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
15-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9425911-Adult,
pubmed-meshheading:9425911-Aged,
pubmed-meshheading:9425911-Blood Pressure,
pubmed-meshheading:9425911-Cohort Studies,
pubmed-meshheading:9425911-Esophageal and Gastric Varices,
pubmed-meshheading:9425911-Female,
pubmed-meshheading:9425911-Hemorrhage,
pubmed-meshheading:9425911-Humans,
pubmed-meshheading:9425911-Liver Cirrhosis,
pubmed-meshheading:9425911-Male,
pubmed-meshheading:9425911-Middle Aged,
pubmed-meshheading:9425911-Predictive Value of Tests,
pubmed-meshheading:9425911-Proportional Hazards Models,
pubmed-meshheading:9425911-Prospective Studies,
pubmed-meshheading:9425911-Regression Analysis,
pubmed-meshheading:9425911-Risk Factors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Variceal pressure is a factor predicting the risk of a first variceal bleeding: a prospective cohort study in cirrhotic patients.
|
| pubmed:affiliation |
Department of Liver and Pancreas Diseases, University Hospital Gasthuisberg, Leuven, Belgium.
|
| pubmed:publicationType |
Journal Article
|