Linked Life Data

9425759

Source:http://linkedlifedata.com/resource/pubmed/id/9425759

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-1-29
pubmed:abstractText
The purpose of this study was to evaluate bone formation and osseointegration using titanium dental implants in the subantral space following surgical implantation of recombinant human bone morphogenetic protein-2 (rhBMP-2). In each of four cynomolgus monkeys, one subantral site was treated with rhBMP-2 (0.19 mg per implant) in an absorbable collagen sponge (ACS). The contralateral site was treated with vehicle in ACS (control). Three months later, two screw-type titanium dental implants were placed into each augmented sinus, and one additional implant was placed immediately anterior to the sinus. Thus, each animal had three experimental sites: rhBMP-2, control, and nonsinus. Animals were sacrificed after an additional 3 months, and block sections were harvested and prepared for histometric analysis. Analysis of variance and t tests were used to evaluate differences between experimental conditions. Mean (+/- SD) vertical bone gain was significantly greater in rhBMP-2 than in control sites (6.0 +/- 0.3 versus 2.6 +/- 0.3 mm; P < .002). Bone density in rhBMP-2 sites averaged 14.4 +/- 2.9% versus 13.9 +/- 4.6% and 14.1 +/- 3.6% for control and nonsinus sites, respectively, without significant differences between experimental conditions. Bone-implant contact in rhBMP-2 sites (41.4 +/- 7.7%) was not significantly different from that in control (38.9 +/- 12.4%) and nonsinus sites (46.8 +/- 10.6%). The present study provides evidence for considerable vertical bone gain in the subantral space following surgical implantation of rhBMP-2, thus allowing placement of dental implants. The newly formed bone appears to be of similar quality and to be as suitable for osseointegration as the residual bone in this nonhuman primate model. Thus, surgical implantation of rhBMP-2 appears to have clinical utility and may provide a realistic alternative to autogenous bone grafts for subantral augmentation procedures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0882-2786
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
785-92
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:9425759-Analysis of Variance, pubmed-meshheading:9425759-Animals, pubmed-meshheading:9425759-Bone Density, pubmed-meshheading:9425759-Bone Morphogenetic Protein 2, pubmed-meshheading:9425759-Bone Morphogenetic Proteins, pubmed-meshheading:9425759-Collagen, pubmed-meshheading:9425759-Dental Implantation, Endosseous, pubmed-meshheading:9425759-Dental Implants, pubmed-meshheading:9425759-Dental Prosthesis Design, pubmed-meshheading:9425759-Drug Carriers, pubmed-meshheading:9425759-Follow-Up Studies, pubmed-meshheading:9425759-Gelatin Sponge, Absorbable, pubmed-meshheading:9425759-Humans, pubmed-meshheading:9425759-Macaca fascicularis, pubmed-meshheading:9425759-Male, pubmed-meshheading:9425759-Maxilla, pubmed-meshheading:9425759-Maxillary Sinus, pubmed-meshheading:9425759-Osseointegration, pubmed-meshheading:9425759-Osteogenesis, pubmed-meshheading:9425759-Osteotomy, pubmed-meshheading:9425759-Recombinant Proteins, pubmed-meshheading:9425759-Titanium, pubmed-meshheading:9425759-Transforming Growth Factor beta
pubmed:articleTitle
Bone formation and osseointegration stimulated by rhBMP-2 following subantral augmentation procedures in nonhuman primates.
pubmed:affiliation
Department of Prosthodontics, University of Aachen, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't