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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0018787,
umls-concept:C0023688,
umls-concept:C0038952,
umls-concept:C0205263,
umls-concept:C0332206,
umls-concept:C0443252,
umls-concept:C0450127,
umls-concept:C0870134,
umls-concept:C1516240,
umls-concept:C1704259,
umls-concept:C1705987
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pubmed:issue |
12
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pubmed:dateCreated |
1998-1-22
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pubmed:abstractText |
Failure of costimulatory molecule-deficient donor dendritic cells (DCs) to induce indefinite allograft acceptance may be a result of the 'late" up-regulation of these molecules on the DCs after interaction with host T cells. Ligation of CD40 on antigen-presenting cells by its cognate ligand CD40L is thought to induce expression of CD80 (B7-1) and CD86 (B7-2). We examined the influence of anti-CD40L monoclonal antibody (mAb) on the capacity of donor-derived DC progenitors to induce long-term allograft survival.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0041-1337
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1808-15
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9422424-Animals,
pubmed-meshheading:9422424-Antibodies, Monoclonal,
pubmed-meshheading:9422424-Antigens, CD40,
pubmed-meshheading:9422424-Bone Marrow Cells,
pubmed-meshheading:9422424-CD40 Ligand,
pubmed-meshheading:9422424-Cytotoxicity, Immunologic,
pubmed-meshheading:9422424-Dendritic Cells,
pubmed-meshheading:9422424-Graft Rejection,
pubmed-meshheading:9422424-Graft Survival,
pubmed-meshheading:9422424-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:9422424-Heart Transplantation,
pubmed-meshheading:9422424-Immunophenotyping,
pubmed-meshheading:9422424-Immunosuppression,
pubmed-meshheading:9422424-Interleukin-4,
pubmed-meshheading:9422424-Male,
pubmed-meshheading:9422424-Membrane Glycoproteins,
pubmed-meshheading:9422424-Mice,
pubmed-meshheading:9422424-Mice, Inbred BALB C,
pubmed-meshheading:9422424-Mice, Inbred C3H,
pubmed-meshheading:9422424-Mice, Inbred C57BL,
pubmed-meshheading:9422424-Spleen,
pubmed-meshheading:9422424-T-Lymphocytes,
pubmed-meshheading:9422424-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:9422424-Time Factors,
pubmed-meshheading:9422424-Tissue Donors,
pubmed-meshheading:9422424-Transforming Growth Factor beta
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|
pubmed:year |
1997
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|
pubmed:articleTitle |
Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival.
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pubmed:affiliation |
Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pennsylvania 15213, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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