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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-2-5
|
| pubmed:abstractText |
Recently abnormal melatonin secretion was demonstrated in hypogonadal male patients which was normalized during testosterone administration. These results suggested that both gonadal steroids and gonadotropins may modulate melatonin secretion, probably by activating specific receptors in the pineal gland. We used immunohistochemistry to localize luteinizing hormone, follicle stimulating hormone, estrogen and androgen receptors in human pineal glands. Tissues were obtained at autopsy from 53 adult males (aged 19-94 years) over a period of 1 year. Positive staining for the four types of receptors was evident in all 53 specimens examined. The percent of positively stained cells revealed a significant seasonal variation of gonadotropin receptors with higher values in the winter than in the summer. Day-night difference was evident only for follicle stimulating hormone-receptors during the summer and winter, with higher values at night. Androgen receptors and estrogen receptors were present in all specimens but did not reveal day-night or seasonal variations. These data demonstrate the presence of gonadotropin and gonadal steroid receptors in the human pineal gland. Gonadotropin receptors exhibited seasonal variation with higher values in the winter.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0361-9230
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
665-70
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9421128-Adult,
pubmed-meshheading:9421128-Aged,
pubmed-meshheading:9421128-Aged, 80 and over,
pubmed-meshheading:9421128-Gonadotropins,
pubmed-meshheading:9421128-Humans,
pubmed-meshheading:9421128-Immunohistochemistry,
pubmed-meshheading:9421128-Male,
pubmed-meshheading:9421128-Middle Aged,
pubmed-meshheading:9421128-Pineal Gland,
pubmed-meshheading:9421128-Receptors, Steroid,
pubmed-meshheading:9421128-Seasons,
pubmed-meshheading:9421128-Testis
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Seasonal variation of gonadotropins and gonadal steroids receptors in the human pineal gland.
|
| pubmed:affiliation |
Department of Endocrinology, Haemek Medical Center, Afula, Israel.
|
| pubmed:publicationType |
Journal Article
|