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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-1-28
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pubmed:abstractText |
Human herpesvirus 8 (HHV-8) is the probable viral etiologic agent for Kaposi's sarcoma. The HHV-8 genome encodes viral interferon regulatory factor (vIRF), a gene product that has homology to the IRF family of transcription factors. We demonstrate that vIRF inhibits responses to type I and type II interferons and blocks IRF-1-mediated transcription. vIRF does not compete with IRF-1 for binding to DNA or complex directly with IRF-1. The ability of vIRF to block IRF-1-mediated transcription is independent of the DNA binding domains of both vIRF and IRF-1. These data suggest that vIRF may contribute to viral pathogenesis and cellular transformation by interfering with interferon- and IRF-1-mediated gene expression through a novel mechanism.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-1281555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-1371248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-1630447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-1658708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-2111015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-2460869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-2475256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-2540952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-2557635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-2813069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-2850164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-3422743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-7489408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-7507207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-7541908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-7556162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-7632932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-7687740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-7700311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-7752756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-7997879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-8021262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-8438157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-8473349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-8524823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-8622878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-8884366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-8892957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-8921401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-8939871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9420276-8962146
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IRF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
701-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9420276-Base Sequence,
pubmed-meshheading:9420276-Binding Sites,
pubmed-meshheading:9420276-Cells, Cultured,
pubmed-meshheading:9420276-DNA Primers,
pubmed-meshheading:9420276-DNA-Binding Proteins,
pubmed-meshheading:9420276-Herpesvirus 8, Human,
pubmed-meshheading:9420276-Humans,
pubmed-meshheading:9420276-Interferon Regulatory Factor-1,
pubmed-meshheading:9420276-Interferon Type I,
pubmed-meshheading:9420276-Interferon-gamma,
pubmed-meshheading:9420276-Phosphoproteins,
pubmed-meshheading:9420276-Repressor Proteins,
pubmed-meshheading:9420276-Sarcoma, Kaposi,
pubmed-meshheading:9420276-Signal Transduction,
pubmed-meshheading:9420276-Transcription, Genetic,
pubmed-meshheading:9420276-Transcription Factors,
pubmed-meshheading:9420276-Transfection,
pubmed-meshheading:9420276-Viral Proteins
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pubmed:year |
1998
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pubmed:articleTitle |
Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription.
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pubmed:affiliation |
Winship Cancer Center, Emory University, Atlanta, Georgia 30322, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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