| pubmed-article:9419365 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9419365 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9419365 | lifeskim:mentions | umls-concept:C0026926 | lld:lifeskim |
| pubmed-article:9419365 | lifeskim:mentions | umls-concept:C0242629 | lld:lifeskim |
| pubmed-article:9419365 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:9419365 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:9419365 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9419365 | pubmed:dateCreated | 1998-2-18 | lld:pubmed |
| pubmed-article:9419365 | pubmed:abstractText | Protective immunity to Mycobacterium tuberculosis is poorly understood, but mounting evidence, at least in animal models, implicates major histocompatibility complex class I-restricted CD8+ T cells as an essential component. By using a highly sensitive assay for single cell interferon gamma release, we screened an array of M. tuberculosis antigen-derived peptides congruent with HLA class I allele-specific motifs. We identified CD8+ T cells specific for epitopes in the early secretory antigenic target 6 during active tuberculosis, after clinical recovery and in healthy contacts. Unrestimulated cells exhibited peptide-specific interferon gamma secretion, whereas lines or clones recognized endogenously processed antigen and showed cytolytic activity. These results provide direct evidence for the involvement of CD8+ cytotoxic T lymphocytes in host defense against M. tuberculosis in humans and support current attempts to generate protective cytotoxic T lymphocyte responses against M. tuberculosis by vaccination. | lld:pubmed |
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| pubmed-article:9419365 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9419365 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9419365 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9419365 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9419365 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9419365 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9419365 | pubmed:author | pubmed-author:AndersenPP | lld:pubmed |
| pubmed-article:9419365 | pubmed:author | pubmed-author:HillA VAV | lld:pubmed |
| pubmed-article:9419365 | pubmed:author | pubmed-author:PasvolGG | lld:pubmed |
| pubmed-article:9419365 | pubmed:author | pubmed-author:BrookesRR | lld:pubmed |
| pubmed-article:9419365 | pubmed:author | pubmed-author:DockrellHH | lld:pubmed |
| pubmed-article:9419365 | pubmed:author | pubmed-author:MalinA SAS | lld:pubmed |
| pubmed-article:9419365 | pubmed:author | pubmed-author:WilkinsonR... | lld:pubmed |
| pubmed-article:9419365 | pubmed:author | pubmed-author:LalvaniAA | lld:pubmed |
| pubmed-article:9419365 | pubmed:author | pubmed-author:PathanA AAA | lld:pubmed |
| pubmed-article:9419365 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9419365 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:9419365 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:9419365 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9419365 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9419365 | pubmed:pagination | 270-5 | lld:pubmed |
| pubmed-article:9419365 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9419365 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9419365 | pubmed:articleTitle | Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis. | lld:pubmed |
| pubmed-article:9419365 | pubmed:affiliation | Molecular Immunology Group, Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom. | lld:pubmed |
| pubmed-article:9419365 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9419365 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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