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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-2-18
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pubmed:abstractText |
Protective immunity to Mycobacterium tuberculosis is poorly understood, but mounting evidence, at least in animal models, implicates major histocompatibility complex class I-restricted CD8+ T cells as an essential component. By using a highly sensitive assay for single cell interferon gamma release, we screened an array of M. tuberculosis antigen-derived peptides congruent with HLA class I allele-specific motifs. We identified CD8+ T cells specific for epitopes in the early secretory antigenic target 6 during active tuberculosis, after clinical recovery and in healthy contacts. Unrestimulated cells exhibited peptide-specific interferon gamma secretion, whereas lines or clones recognized endogenously processed antigen and showed cytolytic activity. These results provide direct evidence for the involvement of CD8+ cytotoxic T lymphocytes in host defense against M. tuberculosis in humans and support current attempts to generate protective cytotoxic T lymphocyte responses against M. tuberculosis by vaccination.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-1280333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-1465432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-1480113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-1509256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-1694970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-2450033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-3114143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-6421492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-7504064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-7525483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-7536870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-7595214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-7638857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-7835957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-7878014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-7897219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-8098550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-8245795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-8557334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-8705858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-8705859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-8778016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-8876215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-8960473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-8975902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-9180075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419365-9294140
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
270-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9419365-Adult,
pubmed-meshheading:9419365-Amino Acid Sequence,
pubmed-meshheading:9419365-Antigens, Bacterial,
pubmed-meshheading:9419365-Bacterial Proteins,
pubmed-meshheading:9419365-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9419365-Histocompatibility Testing,
pubmed-meshheading:9419365-Humans,
pubmed-meshheading:9419365-Interferon-gamma,
pubmed-meshheading:9419365-Molecular Sequence Data,
pubmed-meshheading:9419365-Mycobacterium tuberculosis,
pubmed-meshheading:9419365-T-Lymphocytes, Regulatory,
pubmed-meshheading:9419365-Tuberculosis
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pubmed:year |
1998
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pubmed:articleTitle |
Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis.
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pubmed:affiliation |
Molecular Immunology Group, Institute of Molecular Medicine, Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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