Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-1-27
pubmed:abstractText
Clonal T cell unresponsiveness, or anergy, has been proposed as a mechanism of peripheral tolerance in vivo, and as a potential means of curbing unwanted T cell responses. In this study, anergy was induced in a T helper cell (Th) clone reactive to hemoglobin (Hb) peptide 64-76 by coculture of the T cells with live antigen-presenting cells (APCs) and 74L, a peptide analog of Hb(64-76) that contains a single amino acid substitution of leucine for glycine at position 74, or with a low concentration of the agonist ligand. The anergic state was characterized by blunted proliferation and interleukin (IL) 2 production upon restimulation with Hb(64-76), and was not the result of impaired TCR/CD3 downmodulation. The addition of exogenous IL-12 transiently restored proliferation of the anergic lines, but removal of IL-12 from culture returned the T cells to their nonproliferative state. Interestingly, persistence of the anergic phenotype was observed despite biweekly restimulation with antigen, APCs, and IL-2. Thus, T cell unresponsiveness induced by a peptide produced a stable, persistent anergic state in a Th0 clone that was not reversible by stimulation with IL-2 or -12.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-1313950, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-1354889, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-1370311, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-1656278, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-1739426, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-1739971, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-1830923, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-1833816, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-1900952, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-2153162, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-2831066, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-3016727, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-3029267, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-3035012, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-7536622, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-7540944, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-7546403, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-7584131, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-7595228, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-7595230, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-7600296, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-7753171, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-7931057, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-7973657, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-8001128, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-8011301, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-8294862, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-8305133, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-8468461, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-8483498, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-8609399, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-8638119, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-8658175, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-8691122, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-9120387, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-9126922, http://linkedlifedata.com/resource/pubmed/commentcorrection/9419214-9127150
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
187
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-96
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Persistence of peptide-induced CD4+ T cell anergy in vitro.
pubmed:affiliation
Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't