Linked Life Data

9419203

Source:http://linkedlifedata.com/resource/pubmed/id/9419203

Statements in which the resource exists.
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pubmed-article:9419203pubmed:abstractTextOn the basis of the clinical observation that the cerebrospinal fluid (CSF) of patients with cryptococcal meningitis contains high levels of the chemokine interleukin (IL)-8 but few polymorphonuclear leukocytes (PMNL), the production of IL-8 by cultured brain glial cells after stimulation with two serotypes of cryptococcal capsular polysaccharide glucuronoxylomannan (GXM) was studied, followed by an assessment of the effect of GXM on PMNL migration toward IL-8. GXM serotype A but not D was capable of inducing IL-8 production in human fetal microglial cell but not in astrocyte cultures. When added directly to the PMNL, GXM (both serotypes) potently blocked PMNL migration toward IL-8. The mechanism of GXM's inhibitory effect appeared to involve cross-desensitization. These findings suggest that GXM can induce IL-8 production in the brain but that GXM in the systemic circulation inhibits migration of PMNL toward IL-8.lld:pubmed
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pubmed-article:9419203pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9419203pubmed:articleTitleCryptococcal glucuronoxylomannan induces interleukin (IL)-8 production by human microglia but inhibits neutrophil migration toward IL-8.lld:pubmed
pubmed-article:9419203pubmed:affiliationNeuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation and University of Minnesota Medical School, USA.lld:pubmed
pubmed-article:9419203pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9419203pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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