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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-1-23
|
| pubmed:abstractText |
Recent discoveries in diverse fields of biomedical research have merged to reveal the molecular basis of cell cycle control and a critical role of subverting this homeostatic mechanism in cancer development. At the heart of these processes lies a late G1 checkpoint governed by the "RB pathway" whose molecular composition, functions, and cancer-associated defects are briefly evaluated in this review. This exciting new knowledge raises a plethora of conceptual issues in cell biology, with potential practical implications for biotechnology and medicine.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0014-4827
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
237
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1-6
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:9417859-Animals,
pubmed-meshheading:9417859-Cell Cycle,
pubmed-meshheading:9417859-Cyclin-Dependent Kinases,
pubmed-meshheading:9417859-Homeostasis,
pubmed-meshheading:9417859-Humans,
pubmed-meshheading:9417859-Models, Biological,
pubmed-meshheading:9417859-Neoplasms,
pubmed-meshheading:9417859-Oncogenes,
pubmed-meshheading:9417859-Retinoblastoma Protein
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
The retinoblastoma protein pathway in cell cycle control and cancer.
|
| pubmed:affiliation |
Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark.
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|