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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1998-2-26
|
| pubmed:abstractText |
14C-sucrose in 0.5 microliter of buffered saline was infused over 30 sec into one lateral ventricle, and its subsequent distribution was determined in brain, meninges, cerebral blood vessels, and cerebrospinal fluid (CSF) by quantitative autoradiography. Within 3.5 min, infused radiotracer had moved into the third ventricle, the velum interpositum (an extension of the subarchnoid system that contains many blood vessels), the aqueduct, the mesencephalic and fourth ventricles, and the superior medullary velum (a part of the subarachnoid system that touches the mesencephalic and fourth ventricles). The CSF within both of these velae appears to empty into the quadrigeminal and ambient cisterns. Within 5 min radioactive sucrose was also found in the interpeduncular cistern. About 15% of the injected sucrose quickly left the ventricles and entered these large cisterns. In contrast to most CSF-brain interfaces, little sucrose moved from CSF into the medulla next to the lateral recesses and tissues such as the superior colliculus that lie adjacent to the large CSF cisterns. A thick, multilayered glia limitans visible on electron micrographs seemed to form a CSF-brain barrier at these interfaces. Some of the infused 14C-sucrose persisted in the perivascular spaces and walls of arteries and arterioles for more than 3.5 hr. These findings suggest that CSF may function to deliver various agents and factors to pial and parenchymal arteries and arterioles.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0065-1419
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
70
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
285-7
|
| pubmed:dateRevised |
2004-11-12
|
| pubmed:meshHeading |
pubmed-meshheading:9416348-Animals,
pubmed-meshheading:9416348-Cerebral Ventricles,
pubmed-meshheading:9416348-Cerebrospinal Fluid,
pubmed-meshheading:9416348-Cisterna Magna,
pubmed-meshheading:9416348-Rats,
pubmed-meshheading:9416348-Reference Values,
pubmed-meshheading:9416348-Subarachnoid Space,
pubmed-meshheading:9416348-Time Factors
|
| pubmed:year |
1997
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| pubmed:articleTitle |
The rapid flow of cerebrospinal fluid from ventricles to cisterns via subarachnoid velae in the normal rat.
|
| pubmed:affiliation |
Department of Neurological Surgery, State University of New York, Stony Brook, USA.
|
| pubmed:publicationType |
Journal Article
|