Linked Life Data

9416284

Source:http://linkedlifedata.com/resource/pubmed/id/9416284

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-2-26
pubmed:abstractText
The utilization of cardiopulmonary bypass in neonates, infants and children often requires the use of deep hypothermia at 18 degrees C with occasional periods of circulatory arrest. Thus, marked physiologic extremes of temperature and perfusion are induced. The safety of these techniques appears to be related to the reduction of metabolism, particularly cerebral metabolism. We studied the effect of deep hypothermic circulatory arrest and cardiopulmonary bypass on brain oxygenation using near-infrared spectroscopy. After hypothermic arrest, brain oxygen extraction during severe hypoxia and severe hypotension is diminished. However, these responses remain intact after cardiopulmonary bypass. Additionally, cardiopulmonary bypass, rather than deep hypothermic circulatory arrest alters the cerebral oxygen response to hypercapnia. The primary goal of studying alteration of brain oxygenation during cardiopulmonary bypass and deep hypothermic circulatory arrest is to improve our understanding of the association between these methods and perturbations in hemodynamics and ventilation, so that effective brain protection strategies can be developed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-1419
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
78-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Altered brain oxygen extraction with hypoxia and hypotension following deep hypothermic circulatory arrest.
pubmed:affiliation
Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't