Linked Life Data

9415113

Source:http://linkedlifedata.com/resource/pubmed/id/9415113

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1998-1-15
pubmed:abstractText
The natural variability of behavioral performance of aged rats was used to evaluate the effect of acetyl-L-carnitine (ALCAR) on spatial learning and NGF levels in different brain areas. We used a cluster analysis procedure to subdivide the aged animals into three classes of performance (good, intermediate, and poor). These three classes were equally subdivided into controls and ALCAR-treated animals in order to investigate its effect on spatial retention. The stratification of animals prior to treatment allowed us to highlight the state dependency of the action of ALCAR. The effect of the molecule in improving spatial retention was evident only in the intermediate performance group. Furthermore, the drug reduced the NGF levels in the basal forebrain of treated animals, especially in the intermediate performance group. These results suggest a performance-dependent effect of ALCAR and a nonlinear relationship between NGF levels and learning ability in aged rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0531-5565
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
577-87
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Spatial memory and NGF levels in aged rats: natural variability and effects of acetyl-L-carnitine treatment.
pubmed:affiliation
Institute for Research on Senescence, Sigma Tau S.p.A., Pomezia, Rome, Italy.
pubmed:publicationType
Journal Article