Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1998-2-5
|
pubmed:abstractText |
In an open, controlled, multi-centre clinical field trial, seven 'naturally occurring' outbreaks of acute febrile (rectal temperature > or = 39.5 degrees C) respiratory disease in housed calves were treated with a single antimicrobial agent, and either the non-steroidal anti-inflammatory drug (NSAID) carprofen (n = 95) or flunixin meglumine (n = 92) on an alternate basis. Carprofen was administered as a single subcutaneous injection at a mean dosage of 1.4 mg kg-1 (range 1.2 to 1.9 mg kg-1) body weight on the first day and flunixin meglumine by intravenous injection at a mean dosage of 2.0 mg kg-1 (range 1.2 to 2.6 mg kg-1) body weight on the first 3 consecutive days. All calves were examined clinically immediately prior to initial treatment and on three occasions up to 1 week after the end of treatment. There were no statically significant differences between NSAID groups in reduction of clinical parameters between examinations, or in overall efficacy. This trial demonstrated that a single dose of carprofen was equally effective as three daily doses of flunixin meglumine as adjunctive therapy to antimicrobial treatment in acute respiratory disease in calves.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Carbazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Clonixin,
http://linkedlifedata.com/resource/pubmed/chemical/carprofen,
http://linkedlifedata.com/resource/pubmed/chemical/flunixin meglumine
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
1090-0233
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
154
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
233-41
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9414956-Animals,
pubmed-meshheading:9414956-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:9414956-Body Weight,
pubmed-meshheading:9414956-Carbazoles,
pubmed-meshheading:9414956-Cattle,
pubmed-meshheading:9414956-Cattle Diseases,
pubmed-meshheading:9414956-Clonixin,
pubmed-meshheading:9414956-Disease Outbreaks,
pubmed-meshheading:9414956-Dose-Response Relationship, Drug,
pubmed-meshheading:9414956-Drug Therapy, Combination,
pubmed-meshheading:9414956-Fever,
pubmed-meshheading:9414956-Injections, Intravenous,
pubmed-meshheading:9414956-Injections, Subcutaneous,
pubmed-meshheading:9414956-Lung Diseases,
pubmed-meshheading:9414956-Respiration
|
pubmed:year |
1997
|
pubmed:articleTitle |
Comparison of carprofen and flunixin meglumine as adjunctive therapy in bovine respiratory disease.
|
pubmed:affiliation |
Grampian Pharmaceuticals Limited, Research Division, Cumbria, UK.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial,
Multicenter Study
|