| pubmed-article:9414479 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9414479 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
| pubmed-article:9414479 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:9414479 | lifeskim:mentions | umls-concept:C0021364 | lld:lifeskim |
| pubmed-article:9414479 | lifeskim:mentions | umls-concept:C0018591 | lld:lifeskim |
| pubmed-article:9414479 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9414479 | pubmed:dateCreated | 1998-1-15 | lld:pubmed |
| pubmed-article:9414479 | pubmed:abstractText | The t haplotypes are variant alleles of genes in the proximal region of mouse Chromosome 17, linked together by four inversions. While females carrying two t haplotypes are fertile, males are sterile. Their spermatozoa exhibit severe motility defects and are unable to penetrate zona pellucida-free oocytes. Spermatozoa from males carrying one t haplotype (t/+) exhibit mild motility deficits and a delay in penetration of the zona-free oocyte. The inversions of the t haplotypes contain several genes that cause or contribute to male sterility, at least some of which can be identified by analysis of mice carrying Mus spretus-Mus domesticus recombinant Chromosomes 17. The t haplotypes specify a number of sperm biochemical abnormalities, but these have not been related directly to defects in fertilization. In t/+ males, spermatozoa not bearing the t haplotype are defective in fertilization compared with t-bearing spermatozoa. The mechanism causing this is likely to involve haploid gene expression confined to the t-bearing spermatids. Since many genes situated in the region of the t haplotypes have human homologues, an understanding of t haplotype sterility in mice is expected to contribute significantly to our knowledge of the genetic basis for human sperm dysfunction. | lld:pubmed |
| pubmed-article:9414479 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9414479 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9414479 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9414479 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9414479 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9414479 | pubmed:issn | 1359-6004 | lld:pubmed |
| pubmed-article:9414479 | pubmed:author | pubmed-author:Olds-ClarkePP | lld:pubmed |
| pubmed-article:9414479 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9414479 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:9414479 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9414479 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9414479 | pubmed:pagination | 157-64 | lld:pubmed |
| pubmed-article:9414479 | pubmed:dateRevised | 2005-11-16 | lld:pubmed |
| pubmed-article:9414479 | pubmed:meshHeading | pubmed-meshheading:9414479-... | lld:pubmed |
| pubmed-article:9414479 | pubmed:meshHeading | pubmed-meshheading:9414479-... | lld:pubmed |
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| pubmed-article:9414479 | pubmed:meshHeading | pubmed-meshheading:9414479-... | lld:pubmed |
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| pubmed-article:9414479 | pubmed:meshHeading | pubmed-meshheading:9414479-... | lld:pubmed |
| pubmed-article:9414479 | pubmed:meshHeading | pubmed-meshheading:9414479-... | lld:pubmed |
| pubmed-article:9414479 | pubmed:meshHeading | pubmed-meshheading:9414479-... | lld:pubmed |
| pubmed-article:9414479 | pubmed:meshHeading | pubmed-meshheading:9414479-... | lld:pubmed |
| pubmed-article:9414479 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9414479 | pubmed:articleTitle | Models for male infertility: the t haplotypes. | lld:pubmed |
| pubmed-article:9414479 | pubmed:affiliation | Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA. | lld:pubmed |
| pubmed-article:9414479 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9414479 | pubmed:publicationType | Review | lld:pubmed |
| entrez-gene:20997 | entrezgene:pubmed | pubmed-article:9414479 | lld:entrezgene |
| entrez-gene:21803 | entrezgene:pubmed | pubmed-article:9414479 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9414479 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9414479 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9414479 | lld:pubmed |
