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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-2-2
|
| pubmed:abstractText |
To study the incidence of, the factors associated with, and the effect on survival of anemia in human immunodeficiency virus (HIV)-infected persons, we analyzed data from the longitudinal medical record reviews of 32,867 HIV-infected persons who received medical care from January 1990 through August 1996 in clinics, hospitals, and private medical practices in nine United States cities. We calculated the 1-year incidence of anemia (a hemoglobin level of <10 g/dL or a physician diagnosis of anemia); the adjusted odds ratios showing excess risk of anemia associated with demographic factors, prescribed therapies, and concurrent diseases; the risk of death for patients who developed anemia compared with risk for patients who did not develop anemia; and, of patients who did develop anemia, the risk of death for those who did not recover from anemia compared with the risk for those who did recover. The 1-year incidence of anemia was 36.9% for persons with one or more acquired immunodeficiency syndrome (AIDS)-defining opportunistic illnesses (clinical AIDS), 12.1% for patients with a CD4 count of less than 200 cells/micron or CD4 percentage of <14 but not clinical AIDS (immunologic AIDS), and 3.2% for persons without clinical or immunologic AIDS. Of anemia diagnoses, 22% were identified by physicians as drug related. Incidence of anemia was associated with clinical AIDS, immunologic AIDS, neutropenia, thrombocytopenia, bacterial septicemia, black race, female sex, prescription of zidovudine, fluconazole, and ganciclovir, and lack of prescription of trimethoprim-sulfamethoxazole. The increased risk of death associated with anemia differed by first CD4 count: for patients with a CD4 count of >/=200 cells/microL at the beginning of the survival analysis, the risk of death was 148% (99% confidence interval [CI], 114 to 188) greater for those who developed anemia; for patients whose first CD4 count was <200 cells/microL, the risk of death was 56% (99% CI, 43 to 71) greater for those in whom anemia developed. For persons in whom anemia developed, the risk of death was 170% (99% CI, 132 to 203) greater for persons who did not recover from anemia compared with those who did recover. Anemia is a frequent complication of HIV infection, and its incidence is associated with progression of HIV disease, prescription of certain chemotherapeutics, black race, and female sex. Anemia, particularly anemia that does not resolve, is associated with shorter survival of HIV-infected patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
91
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
301-8
|
| pubmed:dateRevised |
2005-11-16
|
| pubmed:meshHeading |
pubmed-meshheading:9414298-AIDS-Related Opportunistic Infections,
pubmed-meshheading:9414298-Adolescent,
pubmed-meshheading:9414298-Adult,
pubmed-meshheading:9414298-Anemia,
pubmed-meshheading:9414298-Anti-HIV Agents,
pubmed-meshheading:9414298-CD4 Lymphocyte Count,
pubmed-meshheading:9414298-Comorbidity,
pubmed-meshheading:9414298-Continental Population Groups,
pubmed-meshheading:9414298-Disease Progression,
pubmed-meshheading:9414298-Female,
pubmed-meshheading:9414298-HIV Infections,
pubmed-meshheading:9414298-Humans,
pubmed-meshheading:9414298-Incidence,
pubmed-meshheading:9414298-Life Tables,
pubmed-meshheading:9414298-Male,
pubmed-meshheading:9414298-Middle Aged,
pubmed-meshheading:9414298-Population Surveillance,
pubmed-meshheading:9414298-Retrospective Studies,
pubmed-meshheading:9414298-Risk Factors,
pubmed-meshheading:9414298-Sex Factors,
pubmed-meshheading:9414298-Survival Analysis,
pubmed-meshheading:9414298-United States
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Epidemiology of anemia in human immunodeficiency virus (HIV)-infected persons: results from the multistate adult and adolescent spectrum of HIV disease surveillance project.
|
| pubmed:affiliation |
Division of HIV/AIDS Prevention, National Center for HIV, STD, and TB Prevention, Atlanta, Georgia, USA.
|
| pubmed:publicationType |
Journal Article,
Review,
Multicenter Study
|