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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1998-1-26
|
| pubmed:abstractText |
In August 1990 an orthopox virus (OPV) had been isolated from a severe case of a generalized infection with lethal outcome in an immunosuppressed 18-year-old man. In this communication we present a detailed characterization of the causative virus strain. Based on distinct epitope configurations detected by various monoclonal antibodies the isolate could be differentiated from other OPV species and was classified as a cowpox virus (CP). This classification was confirmed by a species-specific PCR assay and by establishing physical maps for the restriction enzymes HindIII and XhoI. Based on serological data of neutralization assays, blocking-ELISAs and Western blotting analysis evidence is provided that the infection had been acquired from a stray cat.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0939-1983
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
13-24
|
| pubmed:dateRevised |
2007-7-23
|
| pubmed:meshHeading |
pubmed-meshheading:9413522-Adolescent,
pubmed-meshheading:9413522-Animals,
pubmed-meshheading:9413522-Antibodies, Viral,
pubmed-meshheading:9413522-Antigens, Viral,
pubmed-meshheading:9413522-Cat Diseases,
pubmed-meshheading:9413522-Cats,
pubmed-meshheading:9413522-Cell Line,
pubmed-meshheading:9413522-Cercopithecus aethiops,
pubmed-meshheading:9413522-Cowpox virus,
pubmed-meshheading:9413522-Fatal Outcome,
pubmed-meshheading:9413522-Humans,
pubmed-meshheading:9413522-Male,
pubmed-meshheading:9413522-Orthopoxvirus,
pubmed-meshheading:9413522-Polymerase Chain Reaction,
pubmed-meshheading:9413522-Poxviridae Infections,
pubmed-meshheading:9413522-Rabbits,
pubmed-meshheading:9413522-Restriction Mapping,
pubmed-meshheading:9413522-Species Specificity,
pubmed-meshheading:9413522-Zoonoses
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Characterization of a cowpox-like orthopox virus which had caused a lethal infection in man.
|
| pubmed:affiliation |
Institute for Medical Microbiology, Infectious and Epidemic Diseases, Veterinary Faculty, Ludwig-Maximilians-University, Munich, Germany.
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|