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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-1-14
|
| pubmed:abstractText |
The presence and distribution of neuropeptide-containing nerves within bronchial surgical specimens has been investigated in bronchitic (n = 12) and in nonbronchitic subjects (n = 7). Lung tissue, obtained from patients undergoing thoracotomy for limited lung lesions, was processed immediately and analyzed for nerves using the streptavidin-biotin complex peroxidase method with antisera to the neural marker protein gene product 9.5 (PGP 9.5) and the neuropeptides vasoactive intestinal peptide (VIP), substance P (SP), calcitonin-gene related peptide (CGRP). There were no significant differences between the two groups with respect to the density of PGP 9.5-, SP-, or CGRP-positive nerves in both the locations assessed (smooth muscle layer and glands). The density of VIP-positive nerves was significantly higher in the glands of bronchitic than in nonbronchitic subjects. A negative relationship was found between the presence of airway inflammation, as indexed by mononuclear cell tissue infiltration, and the density of PGP 9.5-positive nerves in both smooth muscle and glands. Likewise, a relationship was found between the smoking history (packs/yr and age of onset of smoking) and the density of VIP-positive nerves in glands. These findings support a role for VIP in the hallmark of chronic bronchitis, i.e., sputum production.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/Thiolester Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin Thiolesterase,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoactive Intestinal Peptide
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1073-449X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
156
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1963-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9412581-Adult,
pubmed-meshheading:9412581-Aged,
pubmed-meshheading:9412581-Aged, 80 and over,
pubmed-meshheading:9412581-Bronchi,
pubmed-meshheading:9412581-Bronchitis,
pubmed-meshheading:9412581-Calcitonin Gene-Related Peptide,
pubmed-meshheading:9412581-Chronic Disease,
pubmed-meshheading:9412581-Exocrine Glands,
pubmed-meshheading:9412581-Humans,
pubmed-meshheading:9412581-Immunohistochemistry,
pubmed-meshheading:9412581-Male,
pubmed-meshheading:9412581-Middle Aged,
pubmed-meshheading:9412581-Mucus,
pubmed-meshheading:9412581-Nerve Tissue Proteins,
pubmed-meshheading:9412581-Neurons,
pubmed-meshheading:9412581-Smoking,
pubmed-meshheading:9412581-Substance P,
pubmed-meshheading:9412581-Thiolester Hydrolases,
pubmed-meshheading:9412581-Ubiquitin Thiolesterase,
pubmed-meshheading:9412581-Vasoactive Intestinal Peptide
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Increased VIP-positive nerve fibers in the mucous glands of subjects with chronic bronchitis.
|
| pubmed:affiliation |
Institute of Occupational Medicine, University of Padova, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|