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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1998-1-8
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pubmed:abstractText |
Mice rendered completely deficient of the complement components C3 or C4 were used to determine the influence of complement activation in the heterologous phase of the anti-GBM disease model. In wild-type animals the disease is characterized by a neutrophil infiltrate, capillary thrombosis, proteinuria and C3 and C4 deposited within the glomerulus. The early infiltration of neutrophils into the glomeruli is greater in wild-type mice (2.8 +/- 0.3) compared with C3-deficient (1.4 +/- 0.2) and C4-deficient (1.2 +/- 0.003) mice. Deficiency also protects against the subsequent development of proteinuria (2.99 +/- 1.11 mg/24h, 0.059 mg/24h and 0.327 +/- 0.14 mg/24h in wild-type, C3-deficient and C4-deficient mice, respectively) and decreases glomerular capillary thrombosis in both C3- and C4-deficient mice. The degree of protection is greater in the C3-deficient than the C4-deficient animals, suggesting both classical and alternative pathway involvement. These studies support a critical role for complement in the development of anti-GBM disease. However, the protective effect of complement deficiency can be broken if the dose of nephritogenic antibody is increased.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0009-9104
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-9
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pubmed:dateRevised |
2008-11-20
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pubmed:meshHeading |
pubmed-meshheading:9409643-Albuminuria,
pubmed-meshheading:9409643-Animals,
pubmed-meshheading:9409643-Basement Membrane,
pubmed-meshheading:9409643-Complement C3,
pubmed-meshheading:9409643-Complement C4,
pubmed-meshheading:9409643-Female,
pubmed-meshheading:9409643-Glomerulonephritis,
pubmed-meshheading:9409643-Immunohistochemistry,
pubmed-meshheading:9409643-Kidney Glomerulus,
pubmed-meshheading:9409643-Mice,
pubmed-meshheading:9409643-Mice, Inbred C57BL,
pubmed-meshheading:9409643-Neutrophils,
pubmed-meshheading:9409643-Rabbits,
pubmed-meshheading:9409643-Serum Albumin,
pubmed-meshheading:9409643-Thrombosis
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pubmed:year |
1997
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pubmed:articleTitle |
Protection against anti-glomerular basement membrane (GBM)-mediated nephritis in C3- and C4-deficient mice.
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pubmed:affiliation |
Department of Nephrology and Transplantation, Guy's Hospital, UMDS, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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