|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
26
|
|
pubmed:dateCreated |
1998-2-2
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency caused by mutations that affect the WAS protein (WASP) and characterized by cytoskeletal abnormalities in hematopoietic cells. By using the yeast two-hybrid system we have identified a proline-rich WASP-interacting protein (WIP), which coimmunoprecipitated with WASP from lymphocytes. WIP binds to WASP at a site distinct from the Cdc42 binding site and has actin as well as profilin binding motifs. Expression of WIP in human B cells, but not of a WIP truncation mutant that lacks the actin binding motif, increased polymerized actin content and induced the appearance of actin-containing cerebriform projections on the cell surface. These results suggest that WIP plays a role in cortical actin assembly that may be important for lymphocyte function.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-4171085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-7536630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-7565724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-7664343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-7688389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-7737110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-7968536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8069912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8163575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8252614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8252619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8409409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8617195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8625410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8643625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8791404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8798379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8805223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8805332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8810341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8824280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8861907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8895577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8940097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8961624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9405671-8999530
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
23
|
|
pubmed:volume |
94
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
14671-6
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:9405671-Actins,
pubmed-meshheading:9405671-Amino Acid Sequence,
pubmed-meshheading:9405671-Carrier Proteins,
pubmed-meshheading:9405671-Cells, Cultured,
pubmed-meshheading:9405671-Cytoskeletal Proteins,
pubmed-meshheading:9405671-Dimerization,
pubmed-meshheading:9405671-Humans,
pubmed-meshheading:9405671-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:9405671-Lymphocytes,
pubmed-meshheading:9405671-Molecular Sequence Data,
pubmed-meshheading:9405671-Proteins,
pubmed-meshheading:9405671-Wiskott-Aldrich Syndrome,
pubmed-meshheading:9405671-Wiskott-Aldrich Syndrome Protein
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells.
|
|
pubmed:affiliation |
Division of Immunology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
