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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-1-29
|
| pubmed:abstractText |
The postnatal development of the innervation of the muscle layer in the rat urinary bladder was analysed in whole mount preparations using immunohistochemistry against protein gene-product 9.5 (PGP; general neuronal marker), growth-associated protein 43 (GAP), dopamine beta-hydroxylase (DBH), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and substance P (SP). Immunoreactive nerve fibres for all markers were already present at birth. The density of PGP- and GAP-positive nerve fibres was similar and remained constant throughout the postnatal development. The rank order of densities for the other markers relative to PGP was NPY (129-189%) > CGRP (20-63%) > SP (7-23%) > DBH (7-12%) > VIP (2-11%). While the density of presumably efferent VIP- and DBH-positive fibres did not change postnatally, NPY-positive fibres reached adult density at the fifth postnatal day. Sensory CGRP- and SP-positive nerve fibres approached adult levels at the end of the second week, shortly before the micturition reflex was completely developed. The data suggest that a sufficient relative density of sensory and certain efferent elements might be a prerequisite for the development of the mature micturition reflex.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0304-3940
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
24
|
| pubmed:volume |
236
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
29-32
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9404944-Animals,
pubmed-meshheading:9404944-Autonomic Nervous System,
pubmed-meshheading:9404944-Calcitonin Gene-Related Peptide,
pubmed-meshheading:9404944-Female,
pubmed-meshheading:9404944-Immunohistochemistry,
pubmed-meshheading:9404944-Male,
pubmed-meshheading:9404944-Neuromuscular Junction,
pubmed-meshheading:9404944-Neurons, Afferent,
pubmed-meshheading:9404944-Neuropeptide Y,
pubmed-meshheading:9404944-Rats,
pubmed-meshheading:9404944-Rats, Wistar,
pubmed-meshheading:9404944-Urinary Bladder
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Postnatal development of the autonomic and sensory innervation of the musculature in the rat urinary bladder.
|
| pubmed:affiliation |
Physiologisches Institut, Tierärztliche Hochschule, Bischofsholer Damm, Hannover, Germany. hsann@physiology.tiho-hannover.de
|
| pubmed:publicationType |
Journal Article
|