rdf:type |
|
lifeskim:mentions |
umls-concept:C0002199,
umls-concept:C0010583,
umls-concept:C0013089,
umls-concept:C0015133,
umls-concept:C0030705,
umls-concept:C0034656,
umls-concept:C0039512,
umls-concept:C0042679,
umls-concept:C0149925,
umls-concept:C0282461,
umls-concept:C0302523,
umls-concept:C0332283,
umls-concept:C0677874,
umls-concept:C0677908,
umls-concept:C0700325,
umls-concept:C2587213
|
pubmed:issue |
12
|
pubmed:dateCreated |
1998-1-2
|
pubmed:abstractText |
Studies of chemotherapy for patients with small cell lung carcinoma (SCLC) have shown that teniposide (T) may have higher activity than etoposide (E). In this randomized, controlled Phase III study, the authors compared cyclophosphamide, doxorubicin, and vincristine (CAV) with E and CAV with T as induction treatments for patients with SCLC. A second objective of the study was to study patients who had achieved complete response (CR). They were considered for a second randomization to maintenance therapy, in which they would receive either recombinant interferon-alpha (rIFN-alpha) or no treatment.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0008-543X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
80
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2222-9
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:9404698-Adult,
pubmed-meshheading:9404698-Aged,
pubmed-meshheading:9404698-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9404698-Carcinoma, Small Cell,
pubmed-meshheading:9404698-Cyclophosphamide,
pubmed-meshheading:9404698-Doxorubicin,
pubmed-meshheading:9404698-Etoposide,
pubmed-meshheading:9404698-Female,
pubmed-meshheading:9404698-Humans,
pubmed-meshheading:9404698-Interferon-alpha,
pubmed-meshheading:9404698-Lung Neoplasms,
pubmed-meshheading:9404698-Male,
pubmed-meshheading:9404698-Middle Aged,
pubmed-meshheading:9404698-Recombinant Proteins,
pubmed-meshheading:9404698-Survival Analysis,
pubmed-meshheading:9404698-Teniposide,
pubmed-meshheading:9404698-Treatment Outcome,
pubmed-meshheading:9404698-Vincristine
|
pubmed:year |
1997
|
pubmed:articleTitle |
A randomized, controlled phase III study of cyclophosphamide, doxorubicin, and vincristine with etoposide (CAV-E) or teniposide (CAV-T), followed by recombinant interferon-alpha maintenance therapy or observation, in small cell lung carcinoma patients with complete responses.
|
pubmed:affiliation |
Department of Medical Oncology, Univeristy of Ancona, Ospedale Torrette, Italy.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Multicenter Study,
Clinical Trial, Phase III
|