Linked Life Data

9403033

Source:http://linkedlifedata.com/resource/pubmed/id/9403033

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-1-13
pubmed:abstractText
Several studies have suggested a population-wide decline in the quality of human semen during the past three decades, but the mechanism remains unclear. It was proved that damage to the DNA of germ cells would lead to mutation, and 8-hydroxydeoxyguanosine (8-OHdG), one of the major products of oxidative damage to DNA, may serve as one of the important factors to affect the sperm quality. In the present paper, 67 semen samples were collected to analyze the sperm quality (density, sperm number, motility, normal head, etc.), and 8-OHdG was measured in DNA isolated from the same sperm samples. The results showed that a significant inverse correlation exists between 8-OHdG/dG(deoxyguanosine) and sperm density (r = -0.358, p = 0.004), and between 8-OHdG/dG and sperm number (r = -0.389, p = 0.01). The results indicate that endogenous oxidative DNA damage could affect sperm quality and subsequently increase the risk of genetic defects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0027-5107
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
381
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-82
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Does the increase of 8-hydroxydeoxyguanosine lead to poor sperm quality?
pubmed:affiliation
Department of Toxicology, School of Public Health, West China University of Medical Sciences, Sichuan, Chengdu, China.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't