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pubmed-article:940251pubmed:abstractTextThree patients who developed hypothyroidism after x irradiation to the neck are presented. The first two cases demonstrate that patients can develop clinical and chemical hypothyroidism after a very short interval following radiotherapy. Hypothyroidism developed in the first patient in the absence of surgical manipulation of the neck, or a large iodine load 4 months after receiving 6800 rad of x-ray therapy to his neck for carcinoma of the larynx. The second patient developed hypothyroidism approximately 6 months after his radiotherapy for carcinoma of the esophagus. Both of these patients demonstrated high titers of serum antithyroid antibodies. A third patient with Hodgkin's disease did not manifest clinical symptoms and signs of hypothyroidism until 6 years after radiation therapy. These cases demonstrate the variability of onset of hypothyroidism after radiotherapy and emphasize the need for careful evaluation of thyroid function before and after neck irradiation.lld:pubmed
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pubmed-article:940251pubmed:pagination180-4lld:pubmed
pubmed-article:940251pubmed:dateRevised2009-11-11lld:pubmed
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pubmed-article:940251pubmed:articleTitleHypothyroidism after x irradiation to the neck: three case reports and a brief review of the literature.lld:pubmed
pubmed-article:940251pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:940251pubmed:publicationTypeCase Reportslld:pubmed