Linked Life Data

9402220

Source:http://linkedlifedata.com/resource/pubmed/id/9402220

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-1-29
pubmed:abstractText
Nerve growth factor is a well-characterized neurotrophin essential for the development and maintenance of certain central and peripheral neurons. As many neurons affected by aging depend for their survival on a constant supply of neurotrophins, nerve growth factor has been proposed as a possible treatment to prevent aging-associated neurodegeneration. There is evidence that nerve growth factor also plays a role in the immune system and modulates certain aspects of endocrine function. Here we have determined the effects of prolonged peripheral (intraperitoneal) treatment with nerve growth factor on body weight, blood pressure, and serum corticosterone levels in the rat. Our data indicate that intraperitoneally-injected nerve growth factor can affect body weight gain in rats. This effect may not be mediated by nerve growth factor-induced increases in serum corticosterone levels, as exogenous administration of corticosterone did not result in a similar body weight loss. These results show that, as previously reported for intracerebroventricular treatment with nerve growth factor, intraperitoneally-injected nerve growth factor also reduces body weight gain in rats. The data also suggest that exogenous delivery of nerve growth factor as part of therapeutic regimens is likely to have several effects.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0736-5748
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
703-10
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effect of a long-term nerve growth factor treatment on body weight, blood pressure, and serum corticosterone in rats.
pubmed:affiliation
Department of Human Biological Chemistry and Genetics, the University of Texas Medical Branch at Galveston, 77555-0652, USA. giulio@hbcg.utmb.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't