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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1997-12-22
|
| pubmed:abstractText |
We conducted a longitudinal study of participants in phase I and II HIV vaccine safety and immunogenicity trials to examine changes in sexual risk behavior that are associated with risk of HIV transmission. The participants were 48 HIV-negative men and women enrolled in one of two placebo-controlled HIV vaccine trials conducted at San Francisco General Hospital. There was a significant increase in insertive unprotected anal intercourse (UAI) from 9% at baseline (trial entry), to 13% at the month 6 assessment, to 20% at the month 12 assessment (p = .02). The primary predictor of either insertive or receptive UAI during the vaccine trials was having engaged in this behavior prior to entry (p = .001). Higher-risk behavior was also seen among participants who were younger and had multiple sexual partners (each, p = .06) and who indicated that one of their reasons for participation in the vaccine trial was hope of protection from HIV infection (p = .07). These findings indicate that despite instructions otherwise, participants with a history of high-risk behavior or who express hope of protection from HIV infection by enrolling in vaccine trials may be candidates for more intensive risk-behavior counseling prior to and during their participation.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1077-9450
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
266-71
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9402073-AIDS Vaccines,
pubmed-meshheading:9402073-Adult,
pubmed-meshheading:9402073-Controlled Clinical Trials as Topic,
pubmed-meshheading:9402073-Female,
pubmed-meshheading:9402073-HIV Infections,
pubmed-meshheading:9402073-HIV Seropositivity,
pubmed-meshheading:9402073-Homosexuality, Male,
pubmed-meshheading:9402073-Humans,
pubmed-meshheading:9402073-Longitudinal Studies,
pubmed-meshheading:9402073-Male,
pubmed-meshheading:9402073-Mental Recall,
pubmed-meshheading:9402073-Patient Participation,
pubmed-meshheading:9402073-Patient Selection,
pubmed-meshheading:9402073-Risk-Taking,
pubmed-meshheading:9402073-Sexual Behavior,
pubmed-meshheading:9402073-Social Perception,
pubmed-meshheading:9402073-Socioeconomic Factors,
pubmed-meshheading:9402073-Volition
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Risk behavior for HIV infection in participants in preventive HIV vaccine trials: a cautionary note.
|
| pubmed:affiliation |
Center for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, 94105, USA. margaret_chesney@quickmail.ucsf.edu
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|