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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-1-15
|
| pubmed:abstractText |
Mechanochemical models based on the Oster-Murray continuum framework have been applied to a variety of biological settings to obtain an understanding of the morphogenesis of living tissues. Wound-healing in mammalian skin is an important example, because a complex sequence of biochemical and biomechanical responses are orchestrated to close a wound by a combination of new tissue formation and wound contraction. Mechanical interactions between dermal fibroblastic cells and the collagen-rich extracellular matrix are crucial in the development of a contracted wound state. We and others have previously proposed mechanochemical models for wound repair to gain a greater understanding of both normal and abnormal healing. In the present work, the existence of spatially varying equilibria of these models is investigated by using a small-stain approximation and phase-plane techniques, with numerical simulations to confirm the analytical predictions. These results are sources of novel insight into the roles of key biological parameters in determining the mechanical properties of a contracted wound. These methods may also be relevant to other morphogenetic scenarios for which similar mechanochemical models have been proposed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0025-5564
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
147
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
113-29
|
| pubmed:dateRevised |
2009-11-11
|
| pubmed:meshHeading |
pubmed-meshheading:9401354-Animals,
pubmed-meshheading:9401354-Biomechanics,
pubmed-meshheading:9401354-Cell Movement,
pubmed-meshheading:9401354-Collagen,
pubmed-meshheading:9401354-Extracellular Matrix,
pubmed-meshheading:9401354-Fibroblasts,
pubmed-meshheading:9401354-Humans,
pubmed-meshheading:9401354-Mathematics,
pubmed-meshheading:9401354-Models, Biological,
pubmed-meshheading:9401354-Skin,
pubmed-meshheading:9401354-Wound Healing
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Spatially varying equilibria of mechanical models: application to dermal wound contraction.
|
| pubmed:affiliation |
Centre of Mathematical Biology, Mathematical Institute, Oxford, United Kingdom.
|
| pubmed:publicationType |
Journal Article
|